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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Maternal Administration of Busulfan Before in Utero Transplantation of Human Hematopoietic Stem Cells Enhances Engraftments in Sheep
DOI: 10.1016/j.exphem.2012.01.018
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Yutaka Hanazono
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Full-length article
(In Press Accepted Manuscript)
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03 February 2012 |
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Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγnull (NSG) mice
DOI: 10.1016/j.exphem.2012.01.015
Abstract: Delayed engraftment remains a major hurdle following cord blood (CB) transplantation. It may be due, at least in part, to low fucosylation of cell surface molecules important for homing to t...
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Simon N. Robinson,
Paul J. Simmons,
Michael W. Thomas,
Nathalie Brouard,
Jeannie A. Javni,
Suprita Trilok,
Jae-Seung Shim,
Hong Yang,
David Steiner,
William K. Decker,
Dongxia Xing,
Leonard D. Shultz,
Barbara Savoldo,
Gianpietro Dotti,
Catherine M. Bollard,
Leonard Miller,
Richard E. Champlin,
Elizabeth J. Shpall,
Patrick A. Zweidler-McKay
et al.
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Full-length article
(In Press Accepted Manuscript)
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03 February 2012 |
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A Functional Role For The Histone Demethylase Utx In Normal And Malignant Hematopoietic Cells
DOI: 10.1016/j.exphem.2012.01.017
Abstract: UTX, an H3K27Me2/3 demethylase, has been implicated in development, self-renewal and differentiation of various organs and embryonic stem (ES) cells through chromatin modifications and trans...
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Jianing Liu,
Thomas Mercher,
Claudia Scholl,
Kristina Brumme,
D. Gary Gilliland,
Nan Zhu
et al.
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Full-length article
(In Press Accepted Manuscript)
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03 February 2012 |
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Inside This Issue
DOI: 10.1016/j.exphem.2012.01.008
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Miscellaneous
(In Press Uncorrected Proof)
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25 January 2012 |
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Lymphoid progenitors in normal mouse lymph nodes develop into NK cells and T cells in vitro and in vivo
DOI: 10.1016/j.exphem.2012.01.009
Abstract: We have identified a population of normal mouse LN cells, termed LN lymphoid progenitor (LNLP), resembling common lymphoid progenitor (CLP) in the BM. LNLPs lack lineage markers, express CD1...
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Kathrin Warner,
Claudia Luther,
Fumio Takei
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Full-length article
(In Press Accepted Manuscript)
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24 January 2012 |
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Immunomodulatory nonablative conditioning regimen for B-cell lymphoid malignancies
DOI: 10.1016/j.exphem.2012.01.014
Abstract: Twenty six patients with recurrent CD20+ B-cell lymphoid malignancies received fludarabine, cyclophosphamide, and rituximab (FCR) based non-ablative conditioning (NST) followed by either mat...
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Wichai Chinratanalab,
Nishitha Reddy,
John P. Greer,
David Morgan,
Brian Engelhardt,
Adetola Kassim,
Stephen J. Brandt,
Madan Jagasia,
Stacey Goodman,
Bipin N Savani
et al.
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Full-length article
(In Press Accepted Manuscript)
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24 January 2012 |
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A novel and simple hollow-fiber assay for in vivo evaluation of nonpeptidyl thrombopoietin receptor agonists
DOI: 10.1016/j.exphem.2012.01.010
Abstract: Preclinical in vivo assessment of the pharmacologic activity of nonpeptidyl thrombopoietin receptor (TPOR) agonists is very difficult owing to the high species specificity of such agonists. ...
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Cheng-Ying Xie,
Yong-Ping Xu,
Hong-Bing Zhao,
Li-Guang Lou
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Full-length article
(In Press Accepted Manuscript)
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24 January 2012 |
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The adaptor protein NTAL enhances proximal signaling and potentiates corticosteroid-induced apoptosis in T-ALL
DOI: 10.1016/j.exphem.2012.01.011
Abstract: The biology of T-ALL is characterized by functional pre-T-cell receptor (TCR) signaling. NTAL is a non-enzymatic transmembrane adaptor molecule that is involved in the proximal signaling of ...
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Karel Svojgr,
Tomas Kalina,
Veronika Kanderova,
Tereza Skopcova,
Tomas Brdicka,
Jan Zuna
et al.
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Full-length article
(In Press Accepted Manuscript)
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24 January 2012 |
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Consolidative therapy with Stem Cell Transplantation Improves Survival of patients with Mantle Cell Lymphoma following any Induction Regimen
DOI: 10.1016/j.exphem.2012.01.012
Abstract: Intensive induction regimen followed by high dose chemotherapy and autologous stem cell transplantation (auto-SCT) is frequently used to improve outcome in patients with mantle-cell lymphoma...
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Nishitha Reddy,
John P. Greer,
Stacey Goodman,
Kassim Adetola,
David S. Morgan,
Wichai Chinratanalab,
Stephen Brandt,
Brian Englehardt,
Olalekan Oluwole,
Madan H. Jagasia,
Bipin N. Savani
et al.
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Full-length article
(In Press Accepted Manuscript)
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24 January 2012 |
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The carboxyl-terminal region of erythroid-specific 5-aminolevulinate synthase acts as an intrinsic modifier for its catalytic activity and protein stability
DOI: 10.1016/j.exphem.2012.01.013
Abstract: Erythroid-specific 5-aminolevulinate synthase (ALAS2) is essential for hemoglobin production, and a loss-of-function mutation of ALAS2 gene causes X-linked sideroblastic anemia (XLSA). Human...
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Senkottuvelan Kadirvel,
Kazumichi Furuyama,
Hideo Harigae,
Kiriko Kaneko,
Yoshiko Tamai,
Yoji Ishida,
Shigeki Shibahara
et al.
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Full-length article
(In Press Accepted Manuscript)
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24 January 2012 |
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Vitamin-D deficiency, autoimmunity and graft-versus-host-disease risk:Implication for preventive therapy
DOI: 10.1016/j.exphem.2012.01.006
Abstract: The majority of patients after allogeneic stem cell transplantation (HSCT) are expected to have vitamin-D deficiency early post-HSCT due to poor nutritional status and limited sun exposure. ...
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Mona Benrashid,
Kim Moyers,
Mohamad Mohty,
Bipin N. Savani
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Review article
(In Press Accepted Manuscript)
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19 January 2012 |
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Abnormal Differentiation of Erythroid Precursors in p45 NF-E2 -/- Mice
DOI: 10.1016/j.exphem.2012.01.007
Abstract: The transcription factor p45 NF-E2 plays major roles in erythroid and megakaryocytic lineages. Here, we investigated the role of p45 NF-E2 in erythoid differentiationin vivo. Absence of p45 ...
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Jadwiga J. Gasiorek,
Zaynab Nouhi,
Volker Blank
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Full-length article
(In Press Accepted Manuscript)
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19 January 2012 |
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Production of large numbers of plasmacytoid dendritic cells with functional activities from CD34+ hematopoietic progenitor cells: Use of interleukin-3
DOI: 10.1016/j.exphem.2012.01.002
Plasmacytoid dendritic cells (pDC), a subset of dendritic cells characterized by a rapid and massive type-I interferon secretion through the Toll-like receptor pathway in response to viral infection, ...
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Stéphanie Demoulin,
Patrick Roncarati,
Philippe Delvenne,
Pascale Hubert
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Full-length article
(In Press Uncorrected Proof)
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12 January 2012 |
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ABT-737 increases tyrosine kinase inhibitor–induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34+ CD38− population to imatinib
DOI: 10.1016/j.exphem.2012.01.004
Chronic myeloid leukemia (CML) tumorigenicity is driven by the oncogenic BCR-ABL tyrosine kinase. Specific tyrosine kinase inhibitors (TKI) have been designed and are now used for the treatment of CML...
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Kelly Airiau,
François-Xavier Mahon,
Marina Josselin,
Marie Jeanneteau,
Beatrice Turcq,
Francis Belloc
et al.
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Full-length article
(In Press Uncorrected Proof)
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11 January 2012 |
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Tocopherol succinate– and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice
DOI: 10.1016/j.exphem.2012.01.005
The goal of this study was to elucidate the role of α-tocopherol succinate (TS)– and AMD3100-mobilized progenitors in mitigating the ionizing-radiation–induced gastrointestinal syndrome in mice. We de...
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Vijay K. Singh,
Stephen Y. Wise,
Pankaj K. Singh,
Elizabeth J. Ducey,
Oluseyi O. Fatanmi,
Thomas M. Seed
et al.
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Full-length article
(In Press Uncorrected Proof)
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11 January 2012 |
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Critical role of CD4+CD25+ regulatory T cells in preventing murine autoantibody-mediated thrombocytopenia
DOI: 10.1016/j.exphem.2012.01.001
Autoimmune response suppression by regulatory T cells (Tregs) helps to maintain peripheral immune tolerance, and defects in this mechanism are thought to play a role in the pathogenesis of various aut...
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Tetsuya Nishimoto,
Takashi Satoh,
Tsutomu Takeuchi,
Yasuo Ikeda,
Masataka Kuwana
et al.
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Full-length article
(In Press Uncorrected Proof)
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11 January 2012 |
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Sonic hedgehog maintains survival and growth of chronic myeloid leukemia progenitor cells through β-catenin signaling
DOI: 10.1016/j.exphem.2012.01.003
Sonic hedgehog (Shh) signaling plays an important role in many human cancers and cancer stem cells. Here we investigate the activity and functional role of Shh signaling in chronic myeloid leukemia (C...
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Wenxia Su,
Fankai Meng,
Lifang Huang,
Miao Zheng,
Wenli Liu,
Hanying Sun
et al.
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Full-length article
(In Press Uncorrected Proof)
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11 January 2012 |
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Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis
DOI: 10.1016/j.exphem.2011.12.003
Diamond-Blackfan anemia is a congenital hypoproliferative macrocytic anemia and 5q- syndrome myelodysplastic syndrome is an acquired hypoproliferative macrocytic anemia. Their common erythroid phenoty...
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Siobán B. Keel,
Susan Phelps,
Kathleen M. Sabo,
Monique N. O’Leary,
Catherine B. Kirn-Safran,
Janis L. Abkowitz
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm
DOI: 10.1016/j.exphem.2011.12.004
Myelodysplastic syndrome is a complex family of preleukemic diseases in which hematopoietic stem cell defects lead to abnormal differentiation in one or more blood lineages. Disease progression is ass...
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Stephanie N. Zimmer,
Madeleine E. Lemieux,
Bijal P. Karia,
Claudia Day,
Ting Zhou,
Qing Zhou,
Andrew L. Kung,
Uthra Suresh,
Yidong Chen,
Marsha C. Kinney,
Alexander J.R. Bishop,
Vivienne I. Rebel
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
DOI: 10.1016/j.exphem.2011.12.005
Strategies that increase homing to the bone marrow and engraftment efficacy of ex vivo expended CD34+ cells are expected to enhance their clinical utility. Here we report that nicotinamide (NAM), a fo...
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Tony Peled,
Hadas Shoham,
Dorit Aschengrau,
Dima Yackoubov,
Gabi Frei,
Noga Rosenheimer G,
Batya Lerrer,
Haim Y. Cohen,
Arnon Nagler,
Eitan Fibach,
Amnon Peled
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development
DOI: 10.1016/j.exphem.2011.12.006
High levels of the aldehyde dehydrogenase isoform ALDH1A1 are expressed in hematopoietic stem cells (HSCs); however, its importance in these cells remains unclear. Consistent with an earlier report, w...
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Maura Gasparetto,
Sanja Sekulovic,
Chad Brocker,
Patrick Tang,
Anush Zakaryan,
Ping Xiang,
Florian Kuchenbauer,
Maggie Wen,
Katayoon Kasaian,
Marie France Witty,
Patty Rosten,
Ying Chen,
Suzan Imren,
Gregg Duester,
David C. Thompson,
Richard Keith Humphries,
Vasilis Vasiliou,
Clay Smith
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34+ cells
DOI: 10.1016/j.exphem.2011.12.002
Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I, and melanoma differentiation-associated antigen 5 (RIG-I/MDA-5) helicases are known to sense double-stranded RNA (dsRNA) virus and initiate...
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Jiajia Liu,
Yong-Mei Guo,
Makoto Hirokawa,
Keiko Iwamoto,
Kumi Ubukawa,
Yoshihiro Michishita,
Naohito Fujishima,
Hiroyuki Tagawa,
Naoto Takahashi,
Weiguo Xiao,
Junsuke Yamashita,
Toshiaki Ohteki,
Kenichi Sawada
et al.
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Full-length article
(In Press Corrected Proof)
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22 December 2011 |
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Infection of bone marrow cells by dengue virus in vivo
DOI: 10.1016/j.exphem.2011.11.011
Abnormal bone marrow (BM) suppression is one of the hallmarks of dengue virus (DENV) infection in patients. Although the etiology remains unclear, direct viral targeting of the BM has been reasoned to...
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Sansanee Noisakran,
Nattawat Onlamoon,
Hui-Mien Hsiao,
Kristina B. Clark,
Francois Villinger,
Aftab A. Ansari,
Guey Chuen Perng
et al.
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Full-length article
(In Press Corrected Proof)
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21 December 2011 |
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Bone marrow−derived cells do not engraft into skeletal muscle microvasculature but promote angiogenesis after acute injury
DOI: 10.1016/j.exphem.2011.12.001
The skeletal muscle is supported by a vast network of microvessels with the capacity to regenerate in response to injury. However, the dynamics of microvascular repair and the origin of reconstituted ...
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Nicholas Ieronimakis,
Aislinn Hays,
Morayma Reyes
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model
DOI: 10.1016/j.exphem.2011.11.009
The use of umbilical cord blood for allogeneic transplantation has increased dramatically over the past years. However, the limited number of cells available in a single cord blood unit remains a seri...
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Korashon L. Watts,
Veronica Nelson,
Brent L. Wood,
Grant D. Trobridge,
Brian C. Beard,
R. Keith Humphries,
Hans-Peter Kiem
et al.
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Full-length article
(In Press Corrected Proof)
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09 December 2011 |
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Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion
DOI: 10.1016/j.exphem.2011.11.010
Hematopoietic stem cells (HSCs) reside in complex bone marrow microenvironments, where niche-induced signals regulate hematopoiesis. Focal adhesion kinase (Fak) is a nonreceptor protein tyrosine kinas...
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Jiayun Lu,
Yan Sun,
Cesar Nombela-Arrieta,
Karrie P. Du,
Shin-Young Park,
Li Chai,
Carl Walkley,
Hongbo R. Luo,
Leslie E. Silberstein
et al.
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Full-length article
(In Press Corrected Proof)
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09 December 2011 |
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Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation
DOI: 10.1016/j.exphem.2011.11.007
Disruption of ribosomal proteins is associated with hematopoietic phenotypes in cell culture and animal models. Mutations in ribosomal proteins are seen in patients with Diamond Blackfan anemia, a rar...
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Alison M. Taylor,
Jessica M. Humphries,
Richard M. White,
Ryan D. Murphey,
Caroline E. Burns,
Leonard I. Zon
et al.
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Full-length article
(In Press Corrected Proof)
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28 November 2011 |
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Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients
DOI: 10.1016/j.exphem.2011.11.008
It is currently unknown whether the in vitro effects observed with statins in acute myeloid leukemia (AML) cells, including lowering of cholesterol, inhibition of isoprenylation, and sensitization to ...
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Karen van der Weide,
Susan D.P.W.M. de Jonge-Peeters,
Gerwin Huls,
Rudolf S.N. Fehrmann,
Jan Jacob Schuringa,
Folkert Kuipers,
Elisabeth G.E. de Vries,
Edo Vellenga
et al.
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Full-length article
(In Press Uncorrected Proof)
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28 November 2011 |
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Targeted overexpression of an activated N-ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia
DOI: 10.1016/j.exphem.2011.11.006
Multiple myeloma is an incurable malignant expansion of plasma cells in the bone marrow. Although there is no pathognomonic genetic lesion among multiple myeloma patients, activation of the ras gene h...
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Michael A. Linden,
Nicole Kirchhof,
Cathy S. Carlson,
Brian G. Van Ness
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Full-length article
(In Press Corrected Proof)
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24 November 2011 |
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A subset of chronic lymphocytic leukemia patients display reduced levels of PARP1 expression coupled with a defective irradiation-induced apoptosis
DOI: 10.1016/j.exphem.2011.11.005
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease characterized by defects in the DNA damage response and apoptosis. Among the factors involved in these pathways, we focused on the enzyme ...
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Maria Giulia Bacalini,
Simona Tavolaro,
Nadia Peragine,
Marilisa Marinelli,
Simona Santangelo,
Ilaria Del Giudice,
Francesca Romana Mauro,
Valeria Di Maio,
Maria Rosaria Ricciardi,
Paola Caiafa,
Sabina Chiaretti,
Robin Foà,
Anna Guarini,
Anna Reale
et al.
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Full-length article
(In Press Corrected Proof)
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24 November 2011 |
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Para-NO-aspirin inhibits NF-κB and induces apoptosis in B-cell progenitor acute lymphoblastic leukemia
DOI: 10.1016/j.exphem.2011.11.001
Although patients with acute lymphoblastic leukemia (ALL) usually achieve complete remission, disease relapse is common and difficult to treat. Para-NO-aspirin (para-NO-ASA) is a novel drug with demon...
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Naveed I. Khan,
Adam Cisterne,
Rana Baraz,
Kenneth F. Bradstock,
Linda J. Bendall
et al.
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Full-length article
(In Press Corrected Proof)
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18 November 2011 |
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Erratum to Experimental Hematology 2010;38:61-70
DOI: 10.1016/j.exphem.2011.07.001
Title of the publication: Preclinical development of a bridging therapy for radiation casualties
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Erratum
(In Press Uncorrected Proof)
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15 July 2011 |
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Detection of bone marrow−derived lung epithelial cells
DOI: 10.1016/j.exphem.2010.04.011
Studies on the ability of bone marrow−derived cells to adopt the morphology and protein expression pattern of epithelial cells in vivo have expanded rapidly during the last decade, and hundreds of pub...
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Susannah H. Kassmer,
Diane S. Krause
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Review article
(In Press Uncorrected Proof)
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05 May 2010 |
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Stem cell plasticity: Recapping the decade, mapping the future
DOI: 10.1016/j.exphem.2010.04.013
In slightly more than a decade of stem cell plasticity research, 24 peer-reviewed articles have demonstrated plasticity across organ and/or embryonic lineage boundaries at the single-cell level, with ...
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Neil D. Theise
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Review article
(In Press Uncorrected Proof)
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03 May 2010 |