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Inside this issue
26 December 2011
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93-94
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| Letter to the Editor |
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Recovery and rebound of platelet counts in mice after thrombocytopenia induced by combination bortezomib + romidepsin
21 November 2011
Thrombocytopenia (TCP) is a dose-limiting toxicity of histone deacetylase inhibitors in both single-agent and combination therapy strategies. A recent report in Blood by Bishton et al. demonstrated p...
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Cynthia R. Giver,
David L. Jaye,
Edmund K. Waller,
Sagar Lonial
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95-96
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| Experimental Stem Cell Transplantation |
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Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning
15 November 2011
In order to develop minimally toxic bone marrow transplantation (BMT) protocols suitable for use in a wider range of indications, it is important to identify ways to enhance BM engraftment at a given ...
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Elisabeth Schwaiger,
Christoph Klaus,
Veerle Matheeussen,
Ulrike Baranyi,
Nina Pilat,
Haley Ramsey,
Stephan Korom,
Ingrid De Meester,
Thomas Wekerle
et al.
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97-106
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| Malignant Hematopoiesis |
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Bortezomib-resistant nuclear factor κB expression in stem-like cells in mantle cell lymphoma
24 October 2011
Mantle cell lymphoma (MCL) is a subtype of B-cell Non-Hodgkin’s Lymphoma (NHL) and accounts for approximately 6% of all lymphomas. Unlike small lymphocytic lymphoma and chronic lymphocytic lymphoma, w...
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Hyun Joo Jung,
Zheng Chen,
Luis Fayad,
Michael Wang,
Jorge Romaguera,
Larry W. Kwak,
Nami McCarty
et al.
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107-118.e2
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| New Techniques and Technologies |
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On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup
15 November 2011
The interplay between hematopoietic stem and progenitor cells (HSPC) and their local microenvironment is a key mechanism for the organization of hematopoiesis. To quantitatively study this process, a ...
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Nico Scherf,
Katja Franke,
Ingmar Glauche,
Ina Kurth,
Martin Bornhäuser,
Carsten Werner,
Tilo Pompe,
Ingo Roeder
et al.
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119-130.e9
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| Normal Hematopoiesis |
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Role of tumor suppressor p53 in megakaryopoiesis and platelet function
24 October 2011
The pathobiological role of p53 has been widely studied, however, its role in normophysiology is relatively unexplored. We previously showed that p53 knock-down increased ploidy in megakaryocytic cult...
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Pani A. Apostolidis,
Donna S. Woulfe,
Massiel Chavez,
William M. Miller,
Eleftherios T. Papoutsakis
et al.
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131-142.e4
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Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis
04 November 2011
Novel roles for the serine protease plasmin have been implicated recently in physiological and pathological processes. However, whether plasmin is involved in erythropoiesis is not known. In the prese...
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Yurai Okaji,
Yoshihiko Tashiro,
Ismael Gritli,
Chiemi Nishida,
Aki Sato,
Yoko Ueno,
Sandra Del Canto Gonzalez,
Makiko Ohki-Koizumi,
Haruyo Akiyama,
Hiromitsu Nakauchi,
Koichi Hattori,
Beate Heissig
et al.
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143-154
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| Stem Cells |
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Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance
24 October 2011
Leukemia stem cell candidates (LSCC) can be enriched from patients with acute myeloid leukemia by high aldehyde dehydrogenase (ALDH) activity and CD34 expression. We have previously demonstrated the l...
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Dan Ran,
Mario Schubert,
Isabel Taubert,
Volker Eckstein,
Frauke Bellos,
Anna Jauch,
Hui Chen,
Thomas Bruckner,
Rainer Saffrich,
Patrick Wuchter,
Anthony D. Ho
et al.
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155-165.e1
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Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL
21 November 2011
Hematopoietic stem cells (HSCs) are maintained at a very low frequency in adult bone marrow under steady-state conditions. However, it is not fully understood how homeostasis of bone marrow HSCs is ma...
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Nao Suzuki,
Satoshi Yamazaki,
Hideo Ema,
Tomoyuki Yamaguchi,
Hiromitsu Nakauchi,
Satoshi Takaki
et al.
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166-174.e3
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