Experimental Hematology
Volume 38, Issue 11 , Pages 1036-1046.e4 , November 2010

Interferon regulatory factor-8−driven myeloid differentiation is regulated by 12/15-lipoxygenase−mediated redox signaling

  • Michelle Kinder

      Affiliations

    • The Wistar Institute, Philadelphia, Pa., USA
    • Immunology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA
    • ,
  • James E. Thompson

      Affiliations

    • Department of Medicine, Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pa., USA
    • Current address: Departments of Medicine and Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
    • ,
  • Cong Wei

      Affiliations

    • Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pa., USA
    • ,
  • Suresh G. Shelat

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, Pa., USA
    • ,
  • Ian A. Blair

      Affiliations

    • Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, Pa., USA
    • ,
  • Martin Carroll

      Affiliations

    • Immunology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA
    • Department of Medicine, Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pa., USA
    • ,
  • Ellen Puré

      Affiliations

    • The Wistar Institute, Philadelphia, Pa., USA
    • Immunology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA
    • Corresponding Author InformationOffprint requests to: Ellen Puré, Ph.D., The Wistar Institute, 3601 Spruce Street, Room 372, Philadelphia, PA 19104

Received 19 January 2010 ,Revised 18 June 2010 ,Accepted 9 July 2010.

References 

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  2. Friedman AD. Transcriptional control of granulocyte and monocyte development. Oncogene. 2007;26:6816–6828
  3. Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity. 2000;13:155–165
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  6. Tsujimura H, Nagamura-Inoue T, Tamura T, Ozato K. IFN consensus sequence binding protein/IFN regulatory factor-8 guides bone marrow progenitor cells toward the macrophage lineage. J Immunol. 2002;169:1261–1269
  7. Middleton MK, Zukas AM, Rubinstein T, et al. Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease. J Exp Med. 2006;203:2529–2540
  8. Middleton MK, Rubinstein T, Pure E. Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase. J Immunol. 2006;176:265–274
  9. Conrad DJ. The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function. Clin Rev Allergy Immunol. 1999;17:71–89
  10. Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol. 2008;295:C849–C868
  11. Kinder M, Wei C, Shelat SG, et al. Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood. 2010;115:5012–5022
  12. Zhu C, Saberwal G, Lu Y, Platanias LC, Eklund EA. The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. J Biol Chem. 2004;279:50874–50885
  13. Yamamoto T, Sakaguchi N, Hachiya M, Nakayama F, Yamakawa M, Akashi M. Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger. Leukemia. 2009;23:761–769
  14. Nakata S, Matsumura I, Tanaka H, et al. NF-kappaB family proteins participate in multiple steps of hematopoiesis through elimination of reactive oxygen species. J Biol Chem. 2004;279:55578–55586
  15. Sattler M, Winkler T, Verma S, et al. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood. 1999;93:2928–2935
  16. Iiyama M, Kakihana K, Kurosu T, Miura O. Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression. Cell Signal. 2006;18:174–182
  17. Holtschke T, Lohler J, Kanno Y, et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996;87:307–317

PII: S0301-472X(10)00285-7

doi: 10.1016/j.exphem.2010.07.004

Experimental Hematology
Volume 38, Issue 11 , Pages 1036-1046.e4 , November 2010

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