Experimental Hematology
Volume 38, Issue 11 , Pages 1105-1114 , November 2010

Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice

  • Ilias Dimomeletis

      Affiliations

    • Department of General and Vascular Surgery, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    • Drs. Dimomeletis and Deindl contributed equally to this work.
  • ,
  • Elisabeth Deindl

      Affiliations

    • Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University, Munich, Germany
    • Drs. Dimomeletis and Deindl contributed equally to this work.
  • ,
  • Marc Zaruba

      Affiliations

    • Medical Clinic I, Department of Cardiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Michael Groebner

      Affiliations

    • Medical Clinic I, Department of Cardiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Stefan Zahler

      Affiliations

    • Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Saskia M. Laslo

      Affiliations

    • Medical Clinic I, Department of Cardiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Robert David

      Affiliations

    • Medical Clinic I, Department of Cardiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Sawa Kostin

      Affiliations

    • Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
  • ,
  • Markus A. Deutsch

      Affiliations

    • Medical Clinic I, Department of Cardiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Gerd Assmann

      Affiliations

    • Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Josef Mueller-Hoecker

      Affiliations

    • Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Michaela Feuring-Buske

      Affiliations

    • Medical Clinic IIII, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
  • ,
  • Wolfgang M. Franz

      Affiliations

    • Medical Clinic I, Department of Cardiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    • Corresponding Author InformationOffprint requests to: Wolfgang M. Franz, Ph.D., Medizinische Klinik und Poliklinik I der LMU, Klinikum der Universität München-Großhadern, Marchioninistr. 15, D-81377 München

Received 4 February 2010 ,Revised 30 June 2010 ,Accepted 30 June 2010.

References 

  1. Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763–776
  2. Urbanek K, Torella D, Sheikh F, et al. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A. 2005;102:8692–8697
  3. Oh H, Bradfute SB, Gallardo TD, et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A. 2003;100:12313–12318
  4. Hierlihy AM, Seale P, Lobe CG, Rudnicki MA, Megeney LA. The post-natal heart contains a myocardial stem cell population. FEBS Lett. 2002;530:239–243
  5. Mouquet F, Pfister O, Jain M, et al. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005;97:1090–1092
  6. Laugwitz KL, Moretti A, Lam J, et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005;433:647–653
  7. Klug MG, Soonpaa MH, Koh GY, Field LJ. Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest. 1996;98:216–224
  8. Koh GY, Soonpaa MH, Klug MG, et al. Stable fetal cardiomyocyte grafts in the hearts of dystrophic mice and dogs. J Clin Invest. 1995;96:2034–2042
  9. Kolossov E, Bostani T, Roell W, et al. Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med. 2006;203:2315–2327
  10. Sachinidis A, Fleischmann BK, Kolossov E, Wartenberg M, Sauer H, Hescheler J. Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res. 2003;58:278–291
  11. Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol. 2002;30:896–904
  12. Reyes M, Dudek A, Jahagirdar B, Koodie L, Marker PH, Verfaillie CM. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest. 2002;109:337–346
  13. Jiang Y, Henderson D, Blackstad M, Chen A, Miller RF, Verfaillie CM. Neuroectodermal differentiation from mouse multipotent adult progenitor cells. Proc Natl Acad Sci U S A. 2003;100:11854–11860
  14. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418:41–49
  15. Keene CD, Ortiz-Gonzalez XR, Jiang Y, Largaespada DA, Verfaillie CM, Low WC. Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant. 2003;12:201–213
  16. Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest. 2002;109:1291–1302
  17. Serafini M, Dylla SJ, Oki M, et al. Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med. 2007;204:129–139
  18. Ross JJ, Hong Z, Willenbring B, et al. Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells. J Clin Invest. 2006;116:3139–3149
  19. Ulloa-Montoya F, Kidder BL, Pauwelyn KA, et al. Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. Genome Biol. 2007;8:R163
  20. Reyes M, Lund T, Lenvik T, Aguiar D, Koodie L, Verfaillie CM. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 2001;98:2615–2625
  21. David R, Theiss H, Franz WM. Connexin 40 promoter-based enrichment of embryonic stem cell-derived cardiovascular progenitor cells. Cells Tissues Organs. 2008;188:62–69
  22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156–159
  23. Deindl E, Zaruba MM, Brunner S, et al. G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis. FASEB J. 2006;20:956–958
  24. Pelacho B, Nakamura Y, Zhang J, et al. Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction. J Tissue Eng Regen Med. 2007;1:51–59
  25. Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95:379–391
  26. Pesce M, Schoeler HR. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells. 2001;19:271–278
  27. Belema-Bedada F, Uchida S, Martire A, Kostin S, Braun T. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell. 2008;2:566–575
  28. Highfill SL, Kelly RM, O’Shaughnessy MJ, et al. Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming. Blood. 2009;114:693–701
  29. Xia Z, Taylor PR, Locklin RM, Gordon S, Cui Z, Triffitt JT. Innate immune response to human bone marrow fibroblastic cell implantation in CB17 scid/beige mice. J Cell Biochem. 2006;98:966–980
  30. Tolar J, O’Shaughnessy MJ, Panoskaltsis-Mortari A, et al. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood. 2006;107:4182–4188

PII: S0301-472X(10)00269-9

doi: 10.1016/j.exphem.2010.06.013

Experimental Hematology
Volume 38, Issue 11 , Pages 1105-1114 , November 2010