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Experimental Hematology
Volume 38, Issue 8
, Pages 609-617
, August 2010
Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling
References
- . Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism. J Biol Chem. 2007;282:10480–10486
- . Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997;94:10919–10924
- . Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood. 2003;102:4191–4197
- . Blood iron homeostasis: newly discovered proteins and iron imbalance. Transfus Med Rev. 2009;23:103–123
- . Iron Metabolism in Man. New York: Oxford University Press; 1979;
- . The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med. 1999;189:831–841
- . Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001;98:3823–3830
- . Divalent metal transporter 1. Hematology. 2005;10:339–345
- Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 2001;509:309–316
- . The G185R mutation disrupts function of the iron transporter Nramp2. Blood. 1998;92:2157–2163
- . Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A. 1998;95:1148–1153
- Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997;16:383–386
- Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A. 1999;96:3143–3148
- . Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 1999;93:4406–4417
- . Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. Blood Cells Mol Dis. 2002;29:488–497
- . Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake. Blood. 2005;106:3985–3987
- . Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med. 1997;185:717–730
- . Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane. Blood. 2003;102:1884–1892
- The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med. 1995;182:655–666
- . Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. J Immunol. 1996;157:3559–3568
- . The Nramp1 protein and its role in resistance to infection and macrophage function. Proc Assoc Am Physicians. 1999;111:283–289
- . Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport. Curr Opin Microbiol. 2000;3:43–48
- . Nramp1 equips macrophages for efficient iron recycling. Exp Hematol. 2008;36:929–937
- Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo. Proc Natl Acad Sci U S A. 2009;106:5960–5965
- . Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake. Chem Biol. 2006;13:965–972
- . A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents. Biochim Biophy Acta. 1979;586:278–297
- . Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms. Exp Hematol. 2008;36:1227–1235
- . Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. Am J Physiol. 1995;269:H648–H655
- . Intracellular labile iron. Intl J Biochem Cell Biol. 2008;40:350–354
- . Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J Biol Chem. 1995;270:24209–24215
- . Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 (NRAMP2, Slc11A2). Biochemistry. 2006;45:2294–2301
- Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999;103:129–135
- . Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783–788
- . Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol. 2003;38:61–88
- . Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta. 2009;1790:682–693
- Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood. 2009;113:5277–5286
- . The ferroportin disease. Blood Cells Mol Dis. 2004;32:131–138
- The hemochromatosis protein HFE inhibits iron export from macrophages. Proc Natl Acad Sci U S A. 2002;99:15602–15607
- . Storage iron regulation. Prog Hematol. 1977;10:105–148
- Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood. 2005;105:1337–1342
- . Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. Blood. 2006;107:4168–4170
- . Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2). Blood. 2006;107:349–354
- Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo. Proc Natl Acad Sci U S A. 2009;106:5960–5965
- Meyron-Holtz E, Gottlieb, Y. Orientation and subcellular localization of heme oxygenase-1. In: Ward R, ed. The European Iron Club. St. Gallen, Switzerland; 2008. p. 39.
PII: S0301-472X(10)00145-1
doi: 10.1016/j.exphem.2010.04.003
© 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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Experimental Hematology
Volume 38, Issue 8
, Pages 609-617
, August 2010
