Experimental Hematology
Volume 38, Issue 8 , Pages 677-684 , August 2010

In vitro deprivation of CD8+CD57+T cells promotes the malignant growth of bone marrow colony cells in patients with lower-risk myelodysplastic syndrome

  • Zhang Zheng

      Affiliations

    • Drs. Zheng and Qianqiao contributed equally as first authors.
  • ,
  • Zhang Qianqiao

      Affiliations

    • Drs. Zheng and Qianqiao contributed equally as first authors.
  • ,
  • He Qi
  • ,
  • Xu Feng
  • ,
  • Chang Chunkang
  • ,
  • Li Xiao

      Affiliations

    • Corresponding Author InformationOffprint requests to: Li Xiao, Ph.D., M.D., Department of Hematology, The Sixth People's Hospital affiliated to Shanghai Jiaotong University, Building NO 600, YiShan Road, Shanghai 200233, PR China

Received 24 October 2009 ,Revised 27 March 2010 ,Accepted 6 April 2010.

References 

  1. Koike M, Ishiyama T, Tomoyasu S, et al. Spontaneous cytokine overproduction by peripheral blood mononuclear cells from patients with myelodysplastic syndromes and aplastic anemia. Leuk Res. 1995;19:639–644
  2. Kitagawa M, Saito I, Kuwata T, et al. Overexpression of tumor necrosis factor (TNF)-alpha and interferon (INF)-gamma by bone marrow cells from patients with myelodysplastic syndromes. Leukemia. 1997;11:2049–2054
  3. Verhoef GE, Schouwer P, Ceuppens JL, et al. Measurement of serum cytokine levels in patients with myelodysplastic syndrome. Leukemia. 1992;6:1268–1272
  4. Molldrem J, Jiang YZ, Stetler-Stevenson M, et al. Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles. Br J Haematol. 1998;102:148–155
  5. Kook H, Zeng W, Guibin C, et al. Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia. Exp Hematol. 2001;29:1270–1277
  6. Matsutani T, Yoshioka T, Tsuruta Y, et al. Determination of T cell receptors of clonal CD8 positive T cells in myelodysplastic syndrome with erythroidhypoplasia. Leuk Res. 2003;27:305–312
  7. Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079–2088
  8. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292–2302
  9. Gonzalez Garcia JR, Meza-Espinoza JP. Use of the International System for Human Cytogenetic Nomenclature (ISCN). Blood. 2006;108:3952–3953
  10. Tarazona R, DelaRosa O, Alonso C, et al. Increased expression of NKcell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev. 2000;121:77–88
  11. Pittet MJ, Speiser DE, Valmori D, et al. Cutting edge: cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression. J Immunol. 2000;164:1148–1152
  12. Baumann I, Scheid C, Koref MS, et al. Autologous lymphocytes inhibit hemopoiesis in long-term culture in patients with myelodysplastic syndrome. Exp Hematol. 2002;30:1405–1411
  13. Sloand EM, Mainwaring L, Fuhrer M, et al. Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome. Blood. 2005;106:841–851
  14. Sloand E, Kim S, Maciejewski JP, et al. Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood. 2002;100:1185–1191
  15. Wu L, Li X, Chang C, et al. Deviation of type I and type II T cells and its negative effect on hematopoiesis in myelodysplastic syndrome. Int J Lab Hematol. 2002;30:390–399
  16. Zang DY, Goodwin RG, Loken MR, et al. Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis. Blood. 2001;98:3058–3065
  17. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996;383:787–793
  18. Meers S, Vandenberghe P, Boogaerts , et al. The clinical significance of activated lymphocytes in patients with myelodysplastic syndromes: a single centre study of 131 patients. Leuk Res. 2008;32:1026–1035
  19. Sloand EM, Kim S, Fuhrer M, et al. Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities. Blood. 2002;100:4427–4432
  20. Sloand EM, Pfannes L, Chen G, et al. CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins. Blood. 2007;109:2399–2405

PII: S0301-472X(10)00144-X

doi: 10.1016/j.exphem.2010.04.002

Experimental Hematology
Volume 38, Issue 8 , Pages 677-684 , August 2010