Experimental Hematology
Volume 38, Issue 8 , Pages 666-676, August 2010

Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of AML cells in vitro and in vivo

  • Jing Yang

      Affiliations

    • Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    • ,
  • Takayuki Ikezoe

      Affiliations

    • Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    • Corresponding Author InformationOffprint requests to: Takayuki Ikezoe, M.D., Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi 783-8505, Japan
    • ,
  • Chie Nishioka

      Affiliations

    • Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    • ,
  • Lei Ni

      Affiliations

    • Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
    • ,
  • H. Phillip Koeffler

      Affiliations

    • Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, Calif., USA
    • ,
  • Akihito Yokoyama

      Affiliations

    • Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan

Received 25 December 2009; received in revised form 8 March 2010; accepted 30 March 2010. published online 12 April 2010.

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PII: S0301-472X(10)00136-0

doi:10.1016/j.exphem.2010.03.020

Experimental Hematology
Volume 38, Issue 8 , Pages 666-676, August 2010

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