« Previous
Next »
Experimental Hematology
Volume 38, Issue 6
, Pages 481-488
, June 2010
Activation of Ras-dependent Elk-1 activity by MLL-AF4 family fusion oncoproteins
References
- . The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Semin Cancer Biol. 2005;15:175–188
- The MLL recombinome of acute leukemias. Leukemia. 2006;20:777–784
- . Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood. 2003;101:633–639
- . Transcriptional activation is a key function encoded by MLL fusion partners. Leukemia. 2003;17:359–365
- . Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell. 2003;4:99–110
- Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell. 2003;4:197–207
- . Targeting RAS signalling pathways in cancer therapy. Nat Rev. 2003;3:11–22
- . Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Development. 2001;128:791–800
- RAS mutations in pediatric leukemias with MLL gene rearrangements. Genes Chromosomes Cancer. 1998;21:270–275
- Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement. Leukemia. 2006;20:218–223
- EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. Proc Natl Acad Sci U S A. 1997;94:2563–2568
- . Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Blood. 2004;103:1445–1453
- . The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication. Nat Cell Biol. 2006;8:717–724
- . The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice. Leukemia. 2006;20:1829–1839
- . Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood. 2005;106:3559–3566
- . Stem cells: self-renewal writ in blood. Nature. 2003;423:231–233
- . Acute myeloid leukemia stem cells. Ann N Y Acad Sci. 2005;1044:1–5
- . Cancer stem cells: lessons from leukemia. Trends Cell Biol. 2005;15:494–501
- . ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. Proc Natl Acad Sci U S A. 2007;104:14442–14447
- The human trithorax protein hASH2 functions as an oncoprotein. Cancer Res. 2008;68:749–758
- Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia. 2009;23:2197–1209
- . RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Blood. 2009;113:1086–1096
PII: S0301-472X(10)00105-0
doi: 10.1016/j.exphem.2010.03.014
© 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Experimental Hematology
Volume 38, Issue 6
, Pages 481-488
, June 2010
