« Previous
Next »
Experimental Hematology
Volume 38, Issue 3
, Pages 174-179
, March 2010
Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia
References
- Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell. 2008;13:483–495
- . Stem cell factor and hematopoiesis. Blood. 1997;90:1345–1364
- . Selection and inbreeding for longevity of a lethal type. J Hered. 1959;50:19–25
- Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J. 1990;9:1805–1813
- . Analysis of the hematopoietic effects of new dominant spotting (W) mutations of the mouse. I. Influence upon hematopoietic stem cells. Exp Hematol. 1983;11:452–460
- Flt3-ligand production by human bone marrow stromal cells. Leukemia. 1996;10:1012–1018
- . The flt3/flk-2 ligand: receptor distribution and action on murine haemopoietic cell survival and proliferation. Leukemia. 1995;9:2058–2066
- Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 2000;95:3489–3497
- . Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 1995;3:147–161
- MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Blood. 2007;110:1639–1647
- High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Blood. 2006;108:3898–3905
- . Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyper proliferation and restores myeloid differentiation. Blood. 2009;114:1596–1606
- . Context dependence of different modules for posttranscriptional enhancement of gene expression from retroviral vectors. Mol Ther. 2000;2:435–445
- . Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 1998;17:3714–3725
- Modelling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal. Blood. 2009;114:3983–3993
- Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation. Blood. 2009;113:1432–1443
- MN1 overexpression is an important step in the development of inv(16) AML. Leukemia. 2007;21:1679–1690
- . Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA. Leukemia. 2005;19:636–643
- . Modeling the initiation and progression of human acute leukemia in mice. Science. 2007;316:600–604
- Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia. Haematologica. 2006;91:ECR09
- Rapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement. Leukemia. 1995;9:2023–2026
- DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet. 2009;41:1207–1215
PII: S0301-472X(10)00011-1
doi: 10.1016/j.exphem.2010.01.003
© 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Experimental Hematology
Volume 38, Issue 3
, Pages 174-179
, March 2010
