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Experimental Hematology
Volume 38, Issue 2
, Pages 124-131.e4
, February 2010
A subpopulation of malignant CD34+CD138+B7-H1+ plasma cells is present in multiple myeloma patients
References
- . Multiple myeloma cancer stem cells. J Clin Oncol. 2008;26:2895–2900
- Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance. Cancer Res. 2008;68:190–197
- . A cellular model for myeloma cell growth and maturation based on an intraclonal CD45 hierarchy. Immunol Rev. 2003;194:105–111
- . PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008;26:677–704
- The hematopoietic stem cell antigen, CD34, is not expressed on the malignant cells in multiple myeloma. Blood. 1994;84:3283–3290
- Peripheral blood stem cell transplantation in myeloma using CD34 selected cells. Bone Marrow Transplant. 1996;17:723–727
- Transplantation of CD34+ peripheral blood progenitor cells after high-dose chemotherapy for patients with advanced multiple myeloma. Blood. 1995;86:390–397
- Detection of clonal immunoglobulin gene rearrangements in the peripheral blood progenitor cells of patients with multiple myeloma: the potential role of purging with CD34 positive selection. Clin Mol Pathol. 1996;49:M112–M117
- CD34 selections from myeloma peripheral blood cell autografts contain residual tumour cells due to impurity, not to CD34+ myeloma cells. Br J Haematol. 1996;93:613–622
- Autologous CD34-selected blood progenitor cell transplants for patients with advanced multiple myeloma. Bone Marrow Transplant. 1998;21:141–145
- . Circulating clonal cells in multiple myeloma do not express CD34 mRNA, as measured by single-cell and real-time RT-PCR assays. Br J Haematol. 1999;107:818–824
- . High numbers of clonal CD19+ cells in the peripheral blood of a patient with multiple myeloma. Br J Haematol. 1999;105:265–267
- . Efficacy and safety of CD34-selected and CD19-depleted autografting in multiple myeloma patients: a pilot study. Exp Hematol. 2002;30:82–88
- Purging of autologous peripheral-blood stem cells using CD34 selection does not improve overall or progression-free survival after high-dose chemotherapy for multiple myeloma: results of a multicenter randomized controlled trial. J Clin Oncol. 2001;19:3771–3779
- Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma. Blood. 1999;93:1858–1868
- G-CSF alone mobilizes sufficient peripheral blood CD34+ cells for positive selection in newly diagnosed patients with myeloma. Br J Haematol. 1996;92:263–268
- Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood. 2007;110:296–304
- . Mobilisation of tumour cells along with CD34+ cells to peripheral blood in multiple myeloma. Eur J Haematol. 2001;67:289–295
- . CD34+ cells in the blood of patients with multiple myeloma express CD19 and IgH mRNA and have patient-specific IgH VDJ gene rearrangements. Blood. 1997;89:1824–1833
- Characterization of clonogenic multiple myeloma cells. Blood. 2004;103:2332–2336
- . The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, and apoptosis-resistant phenotype. Clin Cancer Res. 2005;11:7599–7606
- . Synopsis of a roundtable on validating novel therapeutics for multiple myeloma. Clin Cancer Res. 2006;12:6603–6610
- . Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution. Blood. 2003;101:112–118
- . Analysis of primitive CD34- and CD34+ hematopoietic cells from adults: gain and loss of CD34 antigen by undifferentiated cells are closely linked to proliferative status in culture. Stem Cells. 2004;22:556–569
- . Reversible expression of CD34 by adult human bone marrow long-term engrafting hematopoietic stem cells. Exp Hematol. 2003;31:406–412
PII: S0301-472X(09)00452-4
doi: 10.1016/j.exphem.2009.11.008
© 2010 ISEH - Society for Experimental Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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Experimental Hematology
Volume 38, Issue 2
, Pages 124-131.e4
, February 2010
