Experimental Hematology
Volume 38, Issue 2 , Pages 104-115 , February 2010

Neutrophil elastase–processing defect in cyclic hematopoietic dogs

  • Ronghua Meng

      Affiliations

    • Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, Ala., USA
    • ,
  • Roger Bridgman

      Affiliations

    • Auburn University Hybridoma Facility, Auburn University, Auburn, Ala., USA
    • ,
  • Maria Toivio-Kinnucan

      Affiliations

    • Department of Pathology, College of Veterinary Medicine, Auburn University, Auburn, Ala., USA
    • ,
  • Glenn P. Niemeyer

      Affiliations

    • Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, Ala., USA
    • Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Ala., USA
    • ,
  • William Vernau

      Affiliations

    • School of Veterinary Medicine, University of California, Davis, Calif., USA
    • ,
  • Tommy Hock

      Affiliations

    • Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Ala., USA
    • ,
  • Clinton D. Lothrop Jr.

      Affiliations

    • Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, Ala., USA
    • Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Ala., USA
    • Corresponding Author InformationOffprint requests to: Clinton D. Lothrop, Jr., Ph.D., D.V.M., Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 404 MCLM Building, 1918 University Avenue, Birmingham, AL 35294-0024

Received 13 October 2008 ,Revised 25 September 2009 ,Accepted 30 September 2009.

References 

  1. Bainton DF. Morphology of neutrophils, eosinophils, and basophils. In:  Beutler E,  Lichtman MA,  Coller BS,  Kipps TJ editor. Williams hematology. 5th ed. New York: McGraw-Hill; 1996;p. 753–765
  2. Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood. 1997;89:3503–3521
  3. Gullberg U, Andersson E, Garwicz D, Lindmark A, Olsson I. Biosynthesis, processing and sorting of neutrophil proteins: insight into neutrophil granule development. Eur J Haematol. 1997;58:137–153
  4. Cowland JB, Borregaard N. The individual regulation of granule protein during neutrophil maturation explains the heterogeneity of neutrophil granules. J Leukoc Biol. 1999;66:989–995
  5. Garwicz D, Lennartsson A, Jacobsen SE, Gullberg U, Lindmark A. Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model. Haematologica. 2005;90:38–44
  6. Fouret P, du Bois RM, Bernaudin JF, Takahashi H, Ferrans VJ, Crystal RG. Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J Exp Med. 1989;169:833–845
  7. Cramer EM, Beesley JE, Pulford KAF, Breton-Gorius J, Mason DY. Colocalization of elastase and myeloperoxidase in human blood and bone marrow neutrophils using a monoclonal antibody and immunogold. Am J Pathol. 1989;134:1275–1284
  8. Yoshimura K, Crystal RG. Transcriptional and posttranscriptional modulation of human neutrophil elastase gene expression. Blood. 1992;79:2733–2740
  9. Egesten A, Breton-Gorius J, Guichard J, Gullberg U, Olsson I. The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein. Blood. 1994;83:2985–2994
  10. Hunter MG, Druhan LJ, Massullo PR, Avalos BR. Proteolytic cleavage of granulocyte colony-stimulating factor and its receptor by neutrophil elastase induces growth inhibition and decreased cell surface expression of the granulocyte colony-stimulating factor receptor. Am J Hematol. 2003;74:149–155
  11. Chua F, Laurent GJ. Neutrophil elastase: mediator of extracellular matrix destruction and accumulation. Proc Am Thorac Soc. 2006;3:424–427
  12. Gullberg U, Lindmark A, Lindgren G, Persson AM, Nilsson E, Olsson I. Carboxyl-terminal prodomain-deleted human leukocyte elastase and cathepsin G are efficiently targeted to granules and enzymatically activated in the rat basophilic/mast cell line RBL. J Biol Chem. 1995;270:12912–12918
  13. Lindmark A, Persson AM, Olsson I. Biosynthesis and processing of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937. Blood. 1990;76:2374–2380
  14. El Ouriaghli F, Fujiwara H, Melenhorst JJ, Sconocchia G, Hensel N, Barrett AJ. Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. Blood. 2003;101:1752–1758
  15. Lane A, Ley T. Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice. Cell. 2003;115:305–318
  16. Horwitz M, Benson KF, Duan Z, Li F-Q, Person RE. Hereditary neutropenia: dogs explain human neutrophil elastase mutations. Trends Mol Med. 2004;10:163–170
  17. Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC. Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet. 1999;23:433–436
  18. Horwitz MS, Duan Z, Korkmaz B, Lee HH, Mealiffe ME, Salipante SJ. Neutrophil elastase in cyclic and severe congenital neutropenia. Blood. 2007;109:1817–1824
  19. Carlsson G, Aprikyan AA, Ericson KG, et al. Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden. Haematologica. 2006;91:589–595
  20. Li F-Q, Horwitz M. Characterization of mutant neutrophil elastase in severe congenital neutropenia. J Biol Chem. 2001;276:14230–14241
  21. Lund JE, Padgett GA, Ott RL. Cyclic neutropenia in grey collie dogs. Blood. 1967;29:452–461
  22. Dale DC, Alling DW, Wolff SM. Cyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs. J Clin Invest. 1972;51:2197–2204
  23. Benson KF, Li FQ, Person RE, et al. Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat Genet. 2003;35:90–96
  24. Fontana S, Parolini S, Vermi W, et al. Innate immunity defects in Hermansky-Pudlak type 2 syndrome. Blood. 2006;107:4857–4864
  25. Dell'Angelica EC, Shotelersuk V, Aguilar RC, Gahl WA, Bonifacino JS. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. Mol Cell. 1999;3:11–21
  26. Delshammar M, Ohlsson K. Isolation and partial characterization of elastase from dog granulocytes. Eur J Biochem. 1976;69:125–131
  27. O'Donnell RT, Andersen BR. Characterization of canine neutrophil granules. Infect Immun. 1982;38:351–359
  28. Jones JB, Lange RD, Jones ES. Cyclic hematopoiesis in a colony of dogs. J Am Vet Med Assoc. 1975;166:365–367
  29. Jones JB, Lange RD, Yang TJ, Vodopick H, Jones ES. Canine cyclic neutropenia: erythropoietin and platelet cycles after bone marrow transplantation. Blood. 1975;45:213–219
  30. Jones JB, Yang TJ, Dale JB, Lange RD. Canine cyclic haematopoiesis: marrow transplantation between littermates. Br J Haematol. 1975;30:215–223
  31. Hsieh Y-HP, Ofori JA, Rao Q, Bridgeman RC. Monoclonal antibodies specific to thermostable proteins in animal blood. J Agric Food Chem. 2007;55:6720–6725
  32. Kjeldsen L, Sengelov H, Borregaard N. Subcellular fractionation of human neutrophils on Percoll density gradients. J Immunol Methods. 1999;232:131–143
  33. Fittschen C, Parmley RT, Austin RL, Crist WM. Vicinal glycol-staining identifies secondary granules in human normal and Chédiak-Higashi neutrophils. Anat Rec. 1983;205:301–311
  34. Aikawa M, Atkinson CT. Immunoelectron microscopy of parasites. Adv Parasitol. 1990;29:151–214
  35. Stoll A, Suchodolski JS, Ruaux CG, Steiner JM. Purification and partial characterization of canine neutrophil elastase and the development of an immunoassay for the measurement of canine neutrophil elastase in serum obtained from dogs. Am J Vet Res. 2007;68:584–591
  36. Tapper H, Kallquist L, Johnsson E, Persson A-M, Hansson M, Olsson I. Neutrophil elastase sorting involves plasma membrane trafficking requiring the C-terminal propeptide. Exp Cell Res. 2006;312:3471–3484
  37. Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J Cell Biol. 2004;164:1065–1076
  38. Di Pietro SM, Falcón-Pérez JM, Tenza D, Setty SR, et al. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell. 2006;17:4027–4038

PII: S0301-472X(09)00450-0

doi: 10.1016/j.exphem.2009.09.010

Experimental Hematology
Volume 38, Issue 2 , Pages 104-115 , February 2010

Article Tools

* Image Usage & Resolution