Experimental Hematology
Volume 37, Issue 12 , Pages 1393-1399 , December 2009

Downregulation of GATA-2 and overexpression of adipogenic gene-PPARγ in mesenchymal stem cells from patients with aplastic anemia

  • Yinyan Xu

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yoshiyuki Takahashi

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yue Wang

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Department of Pediatrics, the First Hospital of Jilin University, Changchun, Jilin, China
    • ,
  • Asahito Hama

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Nobuhiro Nishio

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Hideki Muramatsu

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Makito Tanaka

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Nao Yoshida

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Itzel Bustos Villalobos

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Hiroshi Yagasaki

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Seiji Kojima

      Affiliations

    • Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Corresponding Author InformationOffprint requests to: Seiji Kojima, M.D., Ph.D., Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

Received 25 March 2009 ,Revised 12 September 2009 ,Accepted 17 September 2009.

References 

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  2. Bacigalupo A, Valle M, Podesta M, et al. T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia. Exp Hematol. 2005;33:819–827
  3. Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med. 1997;336:1365–1372
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  9. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–147
  10. Tong Q, Tsai J, Hotamisligil GS. GATA transcription factors and fat cell formation. Drug News Perspect. 2003;16:585–588
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  13. Kojima S, Matsuyama T, Kodera Y. Hematopoietic growth factors released by marrow stromal cells from patients with aplastic anemia. Blood. 1992;79:2256–2261
  14. Tong Q, Dalgin G, Xu H, et al. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science. 2000;290:134–138
  15. Selleri C, Maciejewski JP, Sato T, Young NS. Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood. 1996;87:4149–4157
  16. Okitsu Y, Takahashi S, Minegishi N, et al. Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2. Biochem Biophys Res Commun. 2007;364:383–387
  17. Tremain N, Korkko J, Ibberson D, Kopen GC, DiGirolamo C, Phinney DG. MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells. 2001;19:408–418

PII: S0301-472X(09)00366-X

doi: 10.1016/j.exphem.2009.09.005

Experimental Hematology
Volume 37, Issue 12 , Pages 1393-1399 , December 2009

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