Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition

Giammona, Lisa M.; Panuganti, Swapna; Kemper, Jan M.; Apostolidis, Pani A.; Lindsey, Stephan; Papoutsakis, Eleftherios T.; Miller, William M.

doi:10.1016/j.exphem.2009.08.004

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Volume 37, Issue 11 , Pages 1340-1352.e3, November 2009

Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD⁺ levels and SIRT inhibition

Lisa M. Giammona
- Department of Chemical and Biological Engineering, Northwestern University, Evanston, Ill., USA
- Dr. Giammona and Ms. Panuganti contributed equally to this work.
Swapna Panuganti
- Department of Chemical and Biological Engineering, Northwestern University, Evanston, Ill., USA
- Dr. Giammona and Ms. Panuganti contributed equally to this work.
Jan M. Kemper
- Master of Biotechnology Program, Northwestern University, Evanston, Ill., USA
Pani A. Apostolidis
- Department of Chemical and Biological Engineering, Northwestern University, Evanston, Ill., USA
- Delaware Biotechnology Institute, University of Delaware, Newark, Del., USA
Stephan Lindsey
- Delaware Biotechnology Institute, University of Delaware, Newark, Del., USA
- Department of Chemical Engineering, University of Delaware, Newark, Del., USA
Eleftherios T. Papoutsakis
- Department of Chemical and Biological Engineering, Northwestern University, Evanston, Ill., USA
- Delaware Biotechnology Institute, University of Delaware, Newark, Del., USA
- Department of Chemical Engineering, University of Delaware, Newark, Del., USA
William M. Miller
- Department of Chemical and Biological Engineering, Northwestern University, Evanston, Ill., USA
- Master of Biotechnology Program, Northwestern University, Evanston, Ill., USA
- The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Ill., USA
- Offprint requests to: William M. Miller, Ph.D., Northwestern University, 2145 Sheridan Road, Tech E136, Evanston, IL 60208