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Experimental Hematology
Volume 37, Issue 9
, Pages 1121-1130
, September 2009
A proof of concept study: Human C48-placenta immunoregulatory factor is an effective, single therapeutic agent enabling allogeneic, nonmanipulated murine bone marrow transplantation
References
- Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412–415
- . Cytokines: past, present and future. Int J Hematol. 2001;74:3–8
- . Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease. J Clin Invest. 2002;109:1335–1344
- . T cell awareness of paternal alloantigens during pregnancy. Science. 1995;270:630–633
- Soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8. J Immunol. 2000;164:6100–6104
- . Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol. 2004;5:266–271
- Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281:1191–1193
- . PLIF: a novel human ferritin subunit from placenta with immunosuppressive activity. J Biol Chem. 2002;277:12901–12905
- . PLIF induces IL-10 production in monocytes: a calmodulin-p38 mitogen-activated protein kinase-dependent pathway. FASEB J. 2003;17:955–957
- . Placental immodulator ferritin, a novel mmunoregulator, suppresses experimental arthritis. Arthritis Rheum. 2003;48:846–853
- . Placental isoferritin measured by a specific monoclonal antibody as a new predictive marker for premature contraction outcome. Obstet Gynecol. 1989;74:1–3
- . Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Hum Reprod. 2004;19:715–722
- . Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks. Exp Hematol. 2006;34:159–166
- Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. Immunity. 2002;164:161–167
- The topologic and chronologic patterns of hematopoietic cell seeding in host femoral bone marrow after transplantation. Biol Blood Marrow Transplant. 2003;9:496–504
- . In vivo imaging studies of the effect of recipient conditioning, donor cell phenotype and antigen disparity on homing of hematopoietic cells to the bone marrow. Br J Haematol. 2003;120:505–515
- . Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome. J Immunol. 1993;151:5726–5741
- . Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts. Blood. 1995;85:2607–2618
- . Diagnosis of graft-versus-host disease in mice transplanted across minor histocompatibility barriers. Transplantation. 1990;49:1177–1179
- . Allogeneic bone marrow transplantation [review]. Crit Rev Clin Lab Sci. 1983;19:173–186
- . Pathophysiologic mechanisms of acute graft-vs.-host disease [review]. Biol Blood Marrow Transplant. 1999;5:347–356
- . Treatment of recurrent spontaneous abortions by immunization with paternal lymphocytes induces immunosuppression by placental isoferritin. Am J Reprod Immunol. 1993;30:32–36
- . Placental isoferritin as a physiological downregulator of cellular immunoreactivity during pregnancy. Clin Exp Immunol. 1989;77:257–262
- IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol. 2001;166:3789–3796
- . Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med. 1996;184:19–29
- Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta. J Immunol. 1999;163:3684–3691
- . de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10 [review]. Annu Rev Immunol. 1993;11:165–190
- IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell function. Blood. 2003;101:5076–5083Epub 2003 Feb 27
- A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 1997;389:737–742
PII: S0301-472X(09)00212-4
doi: 10.1016/j.exphem.2009.06.002
© 2009 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
« Previous
Experimental Hematology
Volume 37, Issue 9
, Pages 1121-1130
, September 2009
