Experimental Hematology
Volume 37, Issue 7 , Pages 775-783 , July 2009

Problems in the promised land: Status of adult marrow stem cell biology

  • Peter J. Quesenberry

      Affiliations

    • Corresponding Author InformationOffprint requests to: Peter J. Quesenberry, M.D., Department of Medicine, Division of Hematology/Oncology, Warren Alpert Medical School of Brown University and Rhode Island Hospital, 593 Eddy Street, George 3, Providence, RI 02903
    • ,
  • Gerri J. Dooner
    • ,
  • Mark S. Dooner

Received 5 May 2009 ,Revised 5 May 2009 ,Accepted 7 May 2009.

  • Image Result

    Set #1 represents assumed values of mice in which pooled cells were assayed (30% in S phase), while Set #2 represents the actual data from individual mice (mean values: 30%). LT-HSC=long-term hematopo

    Set #1 represents assumed values of mice in which pooled cells were assayed (30% in S phase), while Set #2 represents the actual data from individual mice (mean values: 30%). LT-HSC=long-term hematopoietic stem cells.

  • Image Result
    Mean percent engraftment of marrow from three separate experiments carried out in July. These data represent three different experiments with a total of 15 donor mice per time point. ∗p<0.0004 from

    Mean percent engraftment of marrow from three separate experiments carried out in July. These data represent three different experiments with a total of 15 donor mice per time point. ∗p<0.0004 from hours after light onset (HALO) 8 and 24. From D'Hondt L, McAuliffe C, Damon J, et al. Circadian variations of bone marrow engraftability. J Cell Physiol. 2004;200:63–70, reprinted with permission.

  • Image Result
    Engraftment into nonablated mice.

    Engraftment into nonablated mice.

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    Theoretical stem cell purification resulting in a highly purified, but nonrepresentative stem cell population.

    Theoretical stem cell purification resulting in a highly purified, but nonrepresentative stem cell population.

  • Image Result
    Top bone irradiated with 1,000cGy and bottom not exposed to irradiation. ROS=reactive oxygen species; X=cell death.

    Top bone irradiated with 1,000cGy and bottom not exposed to irradiation. ROS=reactive oxygen species; X=cell death.

PII: S0301-472X(09)00158-1

doi: 10.1016/j.exphem.2009.05.003

Experimental Hematology
Volume 37, Issue 7 , Pages 775-783 , July 2009

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