Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma
Received 7 February 2009; received in revised form 24 March 2009; accepted 26 March 2009. published online 06 April 2009.
Objective
To investigate post-transplant immunotherapy with escalating donor-lymphocyte infusions (DLI) and novel agents (thalidomide, bortezomib, and lenalidomide) to target complete remission (CR).
Materials and Methods
Thirty-two patients with multiple myeloma who achieved only partial remission after allogeneic stem cell transplantation were treated with DLI. If no CR was achieved, one of the novel agents was added to target CR.
Results
CR defined either by European Group for Blood and Marrow Transplantation criteria, flow cytometry, or molecular methods as assessed by patient-specific immunoglobulin H–polymerase chain reaction or plasma cell chimerism polymerase chain reaction was accomplished in 59%, 63%, and 50% of patients, respectively. Achievement of CR resulted in improved 5-year progressive-free and overall survival, according to European Group for Blood and Marrow Transplantation criteria (53% vs 35%; p=0.03 and 90% vs 62%; p=0.06), flow cytometry (74% vs 15%; p=0.001 and 100% vs 52%; p=0.1), or molecular methods (84% vs 38%; p=0.001 and 100% vs 71%; p=0.03).
Conclusions
Our finding demonstrates the clinical relevance of posttransplantation therapies to upgrade remission, and of remission's depth for long-term survival in myeloma patients.
aDepartment for Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg/Germany
bDepartment of Hematology/Oncology, University Medical Center Hamburg-Eppendorf, Hamburg/Germany
cDepartment of Hematology, Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Hashomer/Israel
dDepartment of Hematology, Instituto Nazionale Tumori, University of Milano, Milano/Italy
Offprint requests to: Nicolaus Kröger, M.D., Department for Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
ABSTRACT