Experimental Hematology
Volume 37, Issue 1 , Pages 8-9 , January 2009

Rapid and large increase of the frequency of circulating endothelial colony-forming cells (ECFCs) generating late outgrowth endothelial cells in patients with acute myocardial infarction

  • Margherita Massa

      Affiliations

    • Biotechnology Laboratory, Pavia, Italy
    • Corresponding Author InformationOffprint requests to: Margherita Massa, Ph.D., Biotecnology Laboratory, Fondazione IRCCS Policlinico San Matteo, P. le Golgi 19, 27100, Pavia, Italy
    • ,
  • Rita Campanelli

      Affiliations

    • Clinical Epidemiology Unit, Pavia, Italy
    • ,
  • Elisa Bonetti

      Affiliations

    • Clinical Epidemiology Unit, Pavia, Italy
    • ,
  • Maurizio Ferrario

      Affiliations

    • Department of Cardiology, Pavia, Italy
    • ,
  • Barbara Marinoni

      Affiliations

    • Department of Cardiology, Pavia, Italy
    • ,
  • Vittorio Rosti

      Affiliations

    • Organ Transplantation Laboratory Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

References 

  1. Shintani S, Murohara T, Ikeda H, et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation. 2001;103:2776–2779
  2. Massa M, Rosti V, Ferrario M, et al. Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood. 2005;105:199–206
  3. Wojakowski W, Tendera M, Michalowska A, et al. Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation. 2004;110:3213–3220
  4. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964–967
  5. Case J, Mead LE, Bessler WK, et al. Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol. 2007;35:1109–1118
  6. Ingram DA, Mead LE, Tanaka H, et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood. 2004;104:2752–2760
  7. Huang L, Hou D, Thompson MA, et al. Acute myocardial infarction in swine rapidly and selectively releases highly proliferative endothelial colony forming cells (ECFCs) into circulation. Cell Transplant. 2007;16:887–897
  8. Guven H, Sheperd RM, Bach RG, Capoccia BJ, Link DC. The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. J Am Coll Cardiol. 2006;48:1579–1587
  9. Lipsic E, Voors AA, van Veldhuisen DJ. Serum erythropoietin levels and infarct size. J Am Coll Cardiol. 2006;47:464–471
  10. Ziegler BL, Valtieri M, Porada GA, et al. KDR receptor: a key marker defining hematopoietic stem cells. Science. 1999;285:1553–1558

PII: S0301-472X(08)00436-0

doi: 10.1016/j.exphem.2008.09.007

Experimental Hematology
Volume 37, Issue 1 , Pages 8-9 , January 2009

Article Tools