« Previous
Next »
Experimental Hematology
Volume 36, Issue 12
, Pages 1573-1584
, December 2008
Erythropoietins: A common mechanism of action
References
- . Humoral regulation of red cell production. Blood. 1953;8:349–357
- . Structural characterization of human erythropoietin. J Biol Chem. 1986;261:3116–3121
- . Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53. Mol Cell Biol. 1994;14:4183–4192
- . Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells. J Cell Physiol. 1988;137:65–74
- Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci U S A. 1985;82:7580–7584
- . Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin. Blood. 2001;98:3626–3634
- Enhancement of therapeutic protein in vivo activities through glycoengineering. Nat Biotechnol. 2003;21:414–421
- Role of glycosylation on the secretion and biological activity of erythropoietin. Biochemistry. 1992;31:9871–9876
- . Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. Exp Hematol. 2003;31:290–299
- Pharmacokinetics and pharmacodynamics of intravenous and subcutaneous continuous erythropoietin receptor activator (C.E.R.A.) in patients with chronic kidney disease. Clin J Am Soc Nephrol. 2006;1:1211–1215
- Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency. Kidney Int. 2001;60:741–747
- Randomized, controlled trial of darbepoetin alfa for the treatment of anemia in hemodialysis patients. Am J Kidney Dis. 2002;40:110–118
- . Darbepoetin alfa administered once monthly maintains hemoglobin concentrations in patients with chronic kidney disease. Clin Nephrol. 2005;63:327–334
- Once-monthly subcutaneous C.E.R.A. maintains stable hemoglobin control in patients with chronic kidney disease on dialysis and converted directly from epoetin one to three times weekly. Clin J Am Soc Nephrol. 2007;2:637–646
- Randomized, double-blind, active-controlled trial of every-3-week darbepoetin alfa for the treatment of chemotherapy-induced anemia. J Natl Cancer Inst. 2006;98:273–284
- . Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995;83:59–67
- . Erythropoietin receptor characteristics on primary human erythroid cells. Blood. 1991;77:2583–2590
- Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin. J Clin Invest. 1987;80:357–366
- . Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood. 1988;71:524–527
- Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest. 1988;81:620–623
- Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int. 1993;44:1149–1162
- . Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood. 1991;77:2497–2503
- Erythropoietin: gene cloning, protein structure, and biological properties. Cold Spring Harb Symp Quant Biol. 1986;51(Pt 1):693–702
- . Erythropoietin titers in health and disease. Semin Hematol. 1991;28:2–7
- . Chemotherapy-induced anemia in adults: incidence and treatment. J Natl Cancer Inst. 1999;91:1616–1634
- . Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol. 1989;66:1785–1788
- . Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood. 1989;74:645–651
- Control of rHuEPO biological activity: the role of carbohydrate. Exp Hematol. 2004;32:1146–1155
- . Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med. 1987;316:73–78
- . Erythropoietin titers in anemic, nonuremic patients. J Lab Clin Med. 1987;109:429–433
- . Kinetics of the formed elements of human blood. Blood. 1977;50:699–707
- . Erythropoiesis: normal and abnormal. Semin Hematol. 1967;4:327–336
- . Exercise, training and red blood cell turnover. Sports Med. 1995;19:9–31
- . Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells. J Biol Chem. 1987;262:5554–5562
- . Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood. 1990;76:31–35
- . Expression cloning of the murine erythropoietin receptor. Cell. 1989;57:277–285
- Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998;395:511–516
- . Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction. Biochemistry. 1996;35:1681–1691
- . Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies. J Biol Chem. 1996;271:24691–24697
- . Mapping of the active site of recombinant human erythropoietin. Blood. 1997;89:493–502
- . Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc Natl Acad Sci U S A. 2001;98:4379–4384
- . Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function. J Biol Chem. 2005;280:14844–14854
- Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell. 2003;12:1239–1250
- . Purification of erythroid progenitor cells and characterization of erythropoietin receptors. Br J Cancer Suppl. 1988;9:31–35
- . Quantitation of specific binding of erythropoietin to human erythroid colony-forming cells. J Cell Physiol. 1988;137:337–345
- . Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL. Exp Hematol. 1988;16:836–842
- . Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax. Blood. 2001;98:1374–1381
- . Erythropoietin receptors on murine erythroid colony-forming units: natural history. Blood. 1989;73:1476–1486
- . The erythropoietin receptor of rat erythroid progenitor lens. Characterization and affinity cross-linkage. J Biol Chem. 1987;262:13985–13990
- . Non-infectious complications of transfusion therapy. Blood Rev. 2001;15:69–83
- . Recombinant erythropoietin in urine. Nature. 2000;405:635
- . The first human cell line-derived erythropoietin, epoetin-delta (Dynepo), in the management of anemia in patients with chronic kidney disease. Clin Nephrol. 2007;68:26–31
- . Clinical pharmacokinetic properties of rHuEpo: a review. In: Molineux G, Foot MA, Elliott SG editor. Erythropoietins and Erythropoiesis Molecular, Cellular, Preclinical, and Clinical Biology. Boston: Birkhäuser Basel; 2003;p. 87–112
- Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phlebotomy-induced anemia and bone marrow ablation. Biopharm Drug Dispos. 2004;25:149–156
- . A comparison of nonlinear pharmacokinetics of erythropoietin in sheep and humans. Biopharm Drug Dispos. 1999;20:217–223
- . Pharmacokinetics and distribution of recombinant erythropoietin in rats. Arzneimittelforschung. 1992;42:174–178
- . Mechanism for the nonlinear pharmacokinetics of erythropoietin in rats. J Pharmacol Exp Ther. 1997;283:520–527
- Effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: a minor role of erythropoietin receptor-mediated pathways. [abstract] Nephrol Dial Transplant. 2006;21:iv303–iv304. Abstract MP013
- . Metabolic studies on erythropoietin (EP): II. The role of liver and kidney in the metabolism of Ep. Exp Hematol. 1981;9:796–803
- . The metabolism of erythropoietin in liver cirrhosis patients compared with healthy volunteers. Eur J Haematol. 1995;54:111–116
- . Clinical pharmacokinetics of epoetin (recombinant human erythropoietin). Clin Pharmacokinet. 1991;20:99–113
- . Pharmacokinetics of recombinant human erythropoietin in rabbits and 3/4 nephrectomized rats. Res Commun Mol Pathol Pharmacol. 1997;96:227–240
- . In vivo 125I-erythropoietin pharmacokinetics are unchanged after anesthesia, nephrectomy and hepatectomy in sheep. J Pharmacol Exp Ther. 1996;279:1205–1210
- . Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem. 2006;281:2024–2032
- . Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: evidence for bone marrow as a major erythropoietin elimination pathway. J Pharmacol Exp Ther. 2001;298:820–824
- . Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics. Exp Hematol. 2001;29:425–431
- Effects of chemotherapy on endogenous erythropoietin levels and the pharmacokinetics and erythropoietic response of darbepoetin alfa: a randomised clinical trial of synchronous versus asynchronous dosing of darbepoetin alfa. Eur J Cancer. 2005;41:1140–1149
- . Clinical pharmacology of recombinant human erythropoietin (r-HuEPO). Pharmacotherapy. 1990;10:9S–14S
- . Lymphatic transport of proteins after subcutaneous administration. J Pharm Sci. 2000;89:297–310
- . Tissue distribution and excretion of 125I-darbepoetin alfa in Sprague Dawley rats following a single subcutaneous or intravenous administration abstract]. Nephrol Dial Transpl. 2006;21:iv304. Abstract MP014
- . Bioequivalence and the immunogenicity of biopharmaceuticals. Nat Rev Drug Discov. 2002;1:457–462
- Comparison of epoetin alfa and darbepoetin alfa biological activity under different administration schedules in normal mice. Acta Haematol. 2005;113:163–174
- . New molecules and formulations of recombinant human erythropoietin. In: Molineux G, Foot MA, Elliott SG editor. Erythropoietins and Erythropoiesis Molecular, Cellular, Preclinical, and Clinical Biology. Boston: Birkhäuser Basel; 2003;p. 241–258
- . Darbepoetin alfa is more potent in vivo and can be administered less frequently than rHuEPO. Br J Cancer. 2002;87:476–477
- . Novel strategies for stimulating erythropoiesis and potential new treatments for anaemia. Lancet. 2006;368:947–953
- . New agents that stimulate erythropoiesis. Blood. 2007;109:868–873
- Plasma and lymph pharmacokinetics of recombinant human interleukin-2 and polyethylene glycol-modified interleukin-2 in pigs. J Pharmacol Exp Ther. 2000;293:248–259
- . Chemical and biological properties of polymer-modified proteins. Expert Opin Biol Ther. 2003;3:1253–1261
- . Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions. Biochemistry. 2002;41:14524–14531
- . Peptide mapping and evaluation of glycopeptide microheterogeneity derived from endoproteinase digestion of erythropoietin by affinity high-performance capillary electrophoresis. Anal Chem. 1993;65:1834–1842
- . Carbohydrate structure of erythropoietin expressed in Chinese hamster ovary cells by a human erythropoietin cDNA. J Biol Chem. 1987;262:12059–12076
- . Structures and functional roles of the sugar chains of human erythropoietins. Glycobiology. 1991;1:337–346
- Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients. J Am Soc Nephrol. 1999;10:2392–2395
- . Structured conversion from thrice weekly to weekly erythropoietic regimens using a computerized decision-support system: a randomized clinical study. J Am Soc Nephrol. 2005;16:1463–1470
- . Treatment of anaemia in dialysis patients with unit dosing of darbepoetin alfa at a reduced dose frequency relative to recombinant human erythropoietin (rHuEpo). Nephrol Dial Transplant. 2003;18:362–369
- . Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice. J Pharm Sci. 1994;83:601–606
- Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood. 2002;99:2599–2602
- . PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques. Int J Hematol. 1998;68:1–18
- Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity. Exp Hematol. 2006;34:697–704
- . CERA (Continuous Erythropoietin Receptor Activator): a new erythropoiesis-stimulating agent for the treatment of anemia. Curr Hematol Rep. 2005;4:436–440
- . Comparative erythropoietin receptor binding kinetics of C.E.R.A. and epoetin-beta determined by surface plasmon resonance and competition binding assay. Pharmacology. 2007;81:63–69
- . Site-directed pegylation of recombinant interleukin-2 at its glycosylation site. Biotechnology (N Y). 1990;8:343–346
- . Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation. Life Sci. 1999;65:355–368
- Synthetic erythropoietic proteins: tuning biological performance by site-specific polymer attachment. Chem Biol. 2005;12:371–383
- . Population pharmacokinetic analysis of pegylated human erythropoietin in rats. J Pharm Sci. 2004;93:3027–3038
- Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers. Blood. 2006;108:1830–1834
- Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia. Exp Hematol. 2006;34:1303–1311
- . Is early treatment of anaemia with epoetin-alpha beneficial to pre-dialysis chronic kidney disease patients? Results of a multicentre, open-label, prospective, randomized, comparative group trial. Nephrol Dial Transplant. 2007;22:784–793
- Health-related quality of life associated with recombinant human erythropoietin therapy for predialysis chronic renal disease patients. Am J Kidney Dis. 1995;25:548–554
- Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis. 2005;45:658–666
- Effects of early and late intervention with epoetin alpha on left ventricular mass among patients with chronic kidney disease (stage 3 or 4): results of a randomized clinical trial. J Am Soc Nephrol. 2004;15:148–156
- Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355:2085–2098
- Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 2006;355:2071–2084
- . Clinical benefits and risks associated with epoetin and darbepoetin in patients with chemotherapy-induced anemia: a systematic review of the literature. Clin Ther. 2006;28:801–831
- . Extended epoetin alfa dosing as maintenance treatment for the anemia of chronic kidney disease: the PROMPT study. Clin Nephrol. 2005;64:113–123
- . Epoetin alfa once every 2 weeks is effective for initiation of treatment of anemia of chronic kidney disease. Clin J Am Soc Nephrol. 2007;2:215–221
- Anaemia in haemodialysis patients of five European countries: association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2004;19:121–132
- . Biology of erythropoietin In: Molineux G. In: Foot MA, Elliott SG editor. Erythropoietins and Erythropoiesis Molecular, Cellular, Preclinical, and Clinical Biology. Boston, MA: Birkhäuser Basel; 2003;p. 113–132
S.E. and E.P. are employees of Amgen. I.C.M. has received support grants from Amgen Inc, Ortho Biotech, Roche, and Affymax, and is a consultant for Amgen Inc, Ortho Biotech, Roche, and Affymax.
PII: S0301-472X(08)00388-3
doi: 10.1016/j.exphem.2008.08.003
© 2008 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Experimental Hematology
Volume 36, Issue 12
, Pages 1573-1584
, December 2008
