Experimental Hematology
Volume 36, Issue 12 , Pages 1585-1592 , December 2008

Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression

  • Charlene F. Barroga
  • ,
  • Hang Pham
  • ,
  • Kenneth Kaushansky

      Affiliations

    • Corresponding Author InformationOffprint requests to: Kenneth Kaushansky, M.D., University of California, San Diego, Hematology Division, Department of Pediatrics and Medicine, 9500 Gilman Drive, San Diego, CA 92103-8811

Received 28 November 2007 ,Revised 15 July 2008 ,Accepted 17 July 2008.

References 

  1. Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest. 2005;115:3339–3347
  2. Ramsey RG. c-Myb a stem-progenitor cell regulator in multiple tissue compartments. Growth Factors. 2005;23:253–261
  3. Ganter B, Chao ST, Lipsick JS. Transcriptional activation by the Myb proteins requires a specific local promoter structure. FEBS Lett. 1999;460:401–410
  4. Emambokus N, Vegiopoulos A, Harman B, Jenkinson E, Anderson G. Frampton. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 2003;22:4478–4488
  5. Friedman AD. Runx1, c-Myb, and C/EBPalpha couple differentiation to proliferation or growth arrest during hematopoiesis. J Cell Biochem. 2002;86:624–629
  6. Nakata Y, Shetzline S, Sakashita C, et al. c-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression. Mol Cell Biol. 2007;27:2048–2058
  7. Carpinelli MR, Hilton DJ, Metcalf D, et al. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A. 2004;101:6553–6558
  8. Sandberg ML, Sutton SE, Pletcher MT, et al. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005;8:153–166
  9. Metcalf D, Carpinelli MR, Hyland C, et al. Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood. 2005;105:3480–3487
  10. Mukai HY, Motohashi H, Ohneda O, Suzuki N, Nagano M, Yamamoto M. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol Cell Biol. 2006;26:7953–7965
  11. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood. 1995;86:419–431
  12. Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene. 2002;21:3359–3367
  13. Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999;98:181–191
  14. Collado M, Medema RH, Garcia-Cao I, et al. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem. 2000;275:21960–21968
  15. Schmidt M, Fernandez de Mattos S, van der Horst A, et al. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol. 2002;22:7842–7852
  16. Sevignani C, Calin GA, Siracusa LD, Croce CM. Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome. 2006;17:189–202
  17. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303:83–86
  18. Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435:834–838
  19. Lawrie CH. MicroRNAs and haematology: small molecules, big function. Br J Haematol. 2007;137:503–512
  20. Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF. miR-150 a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A. 2007;104:7080–7085
  21. Felli N, Fontana L, Pelosi E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A. 2005;102:18081–18086
  22. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell. 2003;115:787–798
  23. Ness SA, Kowenz-Leutz E, Casini T, Graf T, Leutz A. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 1993;7:749–759
  24. Garzon R, Pichiorri F, Palumbo T, et al. MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci U S A. 2006;103:5078–5083
  25. Solar GP, Kerr WG, Zeigler FC, et al. Role of c-mpl in early hematopoiesis. Blood. 1998;92:4–10
  26. Fox NE, Priestley GV, Papayannopoulou Th, Kaushansky K. Thrombopoietin (TPO) expands hematopoietic stem cells (HSCs) in vivo. J Clin Invest. 2002;110:389–394
  27. Balduini A, D'Apolito M, Arcelli D, et al. Cord blood expanded CD41+cells: identification of novel components of megakaryocytopoiesis. J Thromb Hemostat. 2006;4:848–860
  28. Vegiopoulos A, Garcia P, Emambokus N, Frampton J. Coordination of erythropoiesis by the transcription factor c-Myb. Blood. 2006;107:4703–4710
  29. Schaefer A, Magócsi M, Stöcker U, Fandrich A, Marquardt H. Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells: the role of calcineurin. J Biol Chem. 1996;271:13484–13490
  30. Guerra J, Withers DA, Boxer LM. Myb binding sites mediate negative regulation of c-myb expression in T- cell lines. Blood. 1995;86:1873–1880
  31. Bloch A, Liu XM, Wang LG. Regulation of c-myb expression in ML-1 human myeloblastic leukemia cells by c-ets-1 protein. Adv Enzyme Regul. 1995;35:35–41
  32. Bartunek P, Kralova J, Blendinger G, Dvorak M, Zenke M. GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter. Oncogene. 2003;22:1927–1935
  33. Lauder A, Castellanos A, Weston K. c-Myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of T cells and is required for PKB-mediated protection from apoptosis. Mol Cell Biol. 2001;21:5797–5805
  34. Bender TP, Thompson CB, Kuehl WM. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science. 1987;237:1473–1476
  35. Sano Y, Ishii S. Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation. J Biol Chem. 2001;276:3674–3682
  36. Verger A, Perdomo J, Crossley M. Modification with SUMO. A role in transcriptional regulation. EMBO Rep. 2003;4:137–142

PII: S0301-472X(08)00347-0

doi: 10.1016/j.exphem.2008.07.001

Experimental Hematology
Volume 36, Issue 12 , Pages 1585-1592 , December 2008