Experimental Hematology
Volume 36, Issue 9 , Pages 1091-1097 , September 2008

Preventive and therapeutic effects of gene therapy using silica nanoparticles–binding of GM-CSF gene on white blood cell production in dogs with leukopenia

  • Eun Wha Choi

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Hye Cheong Koo

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • Veterinary Microbiology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Il Seob Shin

      Affiliations

    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Young Jin Chae

      Affiliations

    • Veterinary Biochemistry, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Jong Hwa Lee

      Affiliations

    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Sei Myoung Han

      Affiliations

    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Seung Jun Lee

      Affiliations

    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Dong Ha Bhang

      Affiliations

    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Yong Ho Park

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • Veterinary Biochemistry, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Chang Woo Lee

      Affiliations

    • Veterinary Clinical Pathology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • ,
  • Hwa Young Youn

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Republic of Korea
    • Corresponding Author InformationOffprint requests to: Hwa Young Youn, D.V.M., P.hD., Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Sillim 9-dong, Gwanak-gu, 151-742, Seoul, Republic of Korea

Received 10 October 2007 ,Revised 15 February 2008 ,Accepted 8 April 2008.

References 

  1. Kociba GJ. Leukocyte changes in disease. In:  Ettinger SJ,  Feldman EC editor. Textbook of Veterinary Internal Medicine. 5th ed. Philadelphia: W.B. Saunders Company; 2000;p. 1842–1860
  2. Latimer KS, Tvedten H. Leukocyte disorders. In:  Willard MD,  Tvedten H,  Turnwald GH editor. Small Animal Clinical Diagnosis by Laboratory Methods. 3rd ed.. Philadelphia: W.B. Saunders Company; 1999;p. 52–74
  3. Ogilvie GK, Obradovich JE, Cooper MF, Walters LM, Salman MD, Boone TC. Use of recombinant canine granulocyte colony-stimulating factor to decrease myelosuppression associated with the administration of mitoxantrone in the dog. J Vet Intern Med. 1992;6:44–47
  4. Kisseberth WC, Gregory MacEwen E. Complications of cancer and its treatment. In:  Withrow SJ,  Gregory MacEwen E editor. Small Animal Clinical Oncology. 3rd ed.. Philadelphia: W.B. Saunders Company; 2001;p. 198–219
  5. Moore AS, Frimberger AE. Principles of chemotherapy. In:  Ettinger SJ,  Feldman EC editor. Textbook of Veterinary Internal Medicine. 5th ed. Philadelphia: W.B. Saunders Company; 2000;p. 484–489
  6. Shin IS, Nam MJ, Park SJ, Youn HY, Han HR. Cloning of canine GM-CSF and SCF genes. J Vet Sci. 2001;2:159–166
  7. Quesniaux VFJ, Jones TC. Granulocyte-macrophage colony stimulating factor. In:  Thomson AW editors. The cytokine handbook. 3rd ed. London: Academic Press; 1998;p. 637–659
  8. Makrides SC. Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol Rev. 1996;60:512–538
  9. Choi JH, Keum KC, Lee SY. Production of recombinant proteins by high cell density culture of Escherichia coli. Chem Eng Sci. 2006;61:876–885
  10. Bharali DJ, Klejbor I, Stachowiak EK, et al. Organically modified silica-nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci U S A. 2005;102:11539–11544
  11. Choi EW, Shin IS, Chae YJ, et al. Effects of GM-CSF gene transfer using silica-nanoparticles as a vehicle on white blood cell production in dogs. Exp Hematol. 2008;Mar 27:[Epub ahead of print]
  12. Kim SK, Demetri GD. Chemotherapy and neutropenia. Hematol Oncol Clin North Am. 1996;10:377–395
  13. Allen DG, Pringle JK, Smith DA, Pasloske K. Description of drugs for small animals. In:  Allen DG,  Pringle JK,  Smith DA,  Pasloske K editor. Handbook of Veterinary Drugs. 2nd ed.. Philadelphia: Lippincott-Raven; 1998;p. 333
  14. Cartmell T, Southgate T, Rees GS, Castro MG, Lowenstein PR, Luheshi GN. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. J Neurosci. 1999;19:1517–1523
  15. Stone D, David A, Bolognani F, Lowenstein PR, Castro MG. Viral vectors for gene delivery and gene therapy within the endocrine system. J Endocrinol. 2000;164:103–118
  16. Choi EW, Shin IS, Youn HY, et al. Gene therapy using non-viral peptide vector in a canine systemic lupus erythematosus model. Vet Immunol Immunopathol. 2005;103:223–233
  17. Ueno H, Li JJ, Tomita H, et al. Quantitative analysis of repeat adenovirus-mediated gene transfer into injured canine femoral arteries. Arterioscler Thromb Vasc Biol. 1995;15:2246–2253
  18. Foley R, Ellis R, Walker I, et al. Intramarrow cytokine gene transfer by adenoviral vectors in dogs. J Hum Gene Ther. 1997;8:545–553

PII: S0301-472X(08)00173-2

doi: 10.1016/j.exphem.2008.04.002

Experimental Hematology
Volume 36, Issue 9 , Pages 1091-1097 , September 2008

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