Experimental Hematology
Volume 36, Issue 7 , Pages 816-822 , July 2008

Early fetal gene delivery utilizes both central and peripheral mechanisms of tolerance induction

Received 14 January 2008 ,Revised 4 February 2008 ,Accepted 11 February 2008.

References 

  1. Coutelle C, Themis M, Waddington SN, et al. Gene therapy progress and prospects: fetal gene therapy—first proofs of concept—some adverse effects. Gene Ther. 2005;12:1601–1607
  2. Porada CD, Park P, Almeida-Porada G, Zanjani ED. The sheep model of in utero gene therapy. Fetal Diagn Ther. 2004;19:23–30
  3. Porada CD, Tran N, Eglitis M, et al. In utero gene therapy: transfer and long-term expression of the bacterial neo(r) gene in sheep after direct injection of retroviral vectors into preimmune fetuses. Human Gene Ther. 1998;9:1571–1585
  4. Tran ND, Porada CD, Zhao Y, Almeida-Porada G, Anderson WF, Zanjani ED. In utero transfer and expression of exogenous genes in sheep. Exp Hematol. 2000;28:17–30
  5. Waddington SN, Buckley SM, David AL, Peebles DM, Rodeck CH, Coutelle C. Fetal gene transfer. Curr Opin Mol Ther. 2007;9:432–438
  6. Tran ND, Porada CD, Almeida-Porada G, Glimp HA, Anderson WF, Zanjani ED. Induction of stable prenatal tolerance to beta-galactosidase by in utero gene transfer into preimmune sheep fetuses. Blood. 2001;97:3417–3423
  7. Waddington SN, Buckley SM, Nivsarkar M, et al. In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor. Blood. 2003;101:1359–1366
  8. Waddington SN, Nivsarkar MS, Mistry AR, et al. Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. Blood. 2004;104:2714–2721
  9. Yang EY, Kim HB, Shaaban AF, Milner R, Adzick NS, Flake AW. Persistent postnatal transgene expression in both muscle and liver after fetal injection of recombinant adenovirus. J Pediatr Surg. 1999;34:766–772discussion 772–763
  10. Bigger BW, Siapati EK, Mistry A, et al. Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther. 2006;13:117–126
  11. Porada CD, Park PJ, Almeida-Porada G, et al. Gestational age of recipient determines pattern and level of transgene expression following in utero retroviral gene transfer. Mol Ther. 2005;11:284–293
  12. Porada CD, Park PJ, Tellez J, et al. Male germ-line cells are at risk following direct-injection retroviral-mediated gene transfer in utero. Mol Ther. 2005;12:754–762
  13. Cock ML, Albuquerque CA, Joyce BJ, Hooper SB, Harding R. Effects of intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep. Am J Obstet Gynecol. 2001;184:209–216
  14. Kutzler MA, Ruane EK, Coksaygan T, Vincent SE, Nathanielsz PW. Effects of three courses of maternally administered dexamethasone at 0.7, 0.75, and 0.8 of gestation on prenatal and postnatal growth in sheep. Pediatrics. 2004;113:313–319
  15. Osgerby JC, Wathes DC, Howard D, Gadd TS. The effect of maternal undernutrition on ovine fetal growth. J Endocrinol. 2002;173:131–141
  16. Vonnahme KA, Hess BW, Hansen TR, et al. Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biol Reprod. 2003;69:133–140
  17. Baumgartner TL, Baumgartner BJ, Hudon L, Moise KJ. Ultrasonographically guided direct gene transfer in utero: successful induction of beta-galactosidase in a rabbit model. Am J Obstet Gynecol. 1999;181:848–852
  18. Peebles D, Gregory LG, David A, et al. Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero. Gene Ther. 2004;11:70–78
  19. Tarantal AF, Lee CI, Ekert JE, et al. Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): lung-targeting approaches. Mol Ther. 2001;4:614–621
  20. Tarantal AF, O'Rourke JP, Case SS, et al. Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systems. Mol Ther. 2001;3:128–138
  21. Liu YJ, Soumelis V, Watanabe N, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol. 2007;25:193–219
  22. Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002;3:673–680
  23. Watanabe N, Hanabuchi S, Soumelis V, et al. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat Immunol. 2004;5:426–434
  24. Watanabe N, Wang YH, Lee HK, et al. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature. 2005;436:1181–1185
  25. Chentoufi AA, Palumbo M, Polychronakos C. Proinsulin expression by Hassall's corpuscles in the mouse thymus. Diabetes. 2004;53:354–359
  26. DeVoss J, Hou Y, Johannes K, et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med. 2006;203:2727–2735
  27. Kekalainen E, Tuovinen H, Joensuu J, et al. A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol. 2007;178:1208–1215
  28. Zhang M, Vacchio MS, Vistica BP, et al. T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form. J Immunol. 2003;170:3954–3962
  29. Munasinghe W, Kireta S, Russ G, Krishnan R. The in vitro suppressive function of immunomagnetically isolated ovine CD4+CD25+ T cells expressing FoxP3 mRNA. Immunol Cell Biol. 2006;84:A4

PII: S0301-472X(08)00073-8

doi: 10.1016/j.exphem.2008.02.007

Experimental Hematology
Volume 36, Issue 7 , Pages 816-822 , July 2008