Experimental Hematology
Volume 36, Issue 7 , Pages 860-870 , July 2008

Interaction of acute lymphopblastic leukemia cells with C-type lectins DC-SIGN and L-SIGN

  • Karlijn Gijzen

      Affiliations

    • Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  • ,
  • Reinier A.P. Raymakers

      Affiliations

    • Department of Hematology, Radboud University Nijmegen Medical Centre, The Netherlands
  • ,
  • Karin M. Broers

      Affiliations

    • Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  • ,
  • Carl G. Figdor

      Affiliations

    • Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
  • ,
  • Ruurd Torensma

      Affiliations

    • Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    • Corresponding Author InformationOffprint requests to: Ruurd Torensma, Ph.D., Department of Tumor Immunology, NCMLS 278, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500HB Nijmegen, The Netherlands

Received 24 August 2007 ,Revised 2 January 2008 ,Accepted 1 February 2008.

References 

  1. Harris NL, Jaffe ES, Diebold J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol. 1999;17:3835–3849
  2. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354:166–178
  3. Lenkei R, Bjork O, Ost A, Biberfeld P. Expression of CD15 as predictor of relapse in children with acute lymphoblastic leukemia of the pre-B type. Leuk Res. 1991;15:189–194
  4. Plasschaert SL, Kamps WA, Vellenga E, de Vries EG, de Bont ES. Prognosis in childhood and adult acute lymphoblastic leukaemia: a question of maturation?. Cancer Treat Rev. 2004;30:37–51
  5. Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med. 1998;339:605–615
  6. Couldrey C, Green JE. Metastases: the glycan connection. Breast Cancer Res. 2000;2:321–323
  7. McCann KJ, Johnson PWM, Stevenson FK, Ottensmeier CH. Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event?. Leukemia. 2006;20:530–534
  8. Dube DH, Bertozzi CR. Glycans in cancer and inflammation–potential for therapeutics and diagnostics. Nat Rev Drug Discov. 2005;4:477–488
  9. Drickamer K. C-type lectin-like domains. Curr Opin Struct Biol. 1999;9:585–590
  10. Cambi A, Figdor CG. Dual function of C-type lectin-like receptors in the immune system. Curr Opin Cell Biol. 2003;15:539–546
  11. Cambi A, Figdor CG. Levels of complexity in pathogen recognition by C-type lectins. Curr Opin Immunol. 2005;17:1–7
  12. McGreal EP, Martinez-Pomares L, Gordon S. Divergent roles for C-type lectins expressed by cells of the innate immune system. Mol Immunol. 2004;41:1109–1121
  13. Gijzen K, Tacken PJ, Zimmerman A, et al. Relevance of DC-SIGN in DC-induced T cell proliferation. J Leukoc Biol. 2007;81:729–740
  14. Geijtenbeek TB, Torensma R, Van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell. 2000;100:575–585
  15. Gijzen K, Cambi A, Torensma R, Figdor CG. C-type lectins on dendritic cells and their interaction with pathogen-derived and endogenous glycoconjugates. Curr Protein Pept Sci. 2006;7:283–294
  16. Guo Y, Feinberg H, Conroy E, et al. Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol. 2004;11:591–598
  17. Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, et al. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J Exp Med. 2001;193:671–678
  18. Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J Immunol. 2000;165:2937–2942
  19. Knolle PA, Limmer A. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol. 2001;22:432–437
  20. Limmer A, Ohl J, Kurts C, et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med. 2000;6:1348–1354
  21. Van Liempt E, Imberty A, Bank CM, et al. Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens. J Biol Chem. 2004;279:33161–33167
  22. Meyer S, Tefsen B, Imberty A, Geyer R, van Die I. The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoni. Glycobiology. 2007;17:1104–1119
  23. Gijzen K, Broers KM, Beeren IM, Figdor CG, Torensma R. Binding of the adhesion and pathogen receptor DC-SIGN by monocytes is regulated by the density of Lewis X molecules. Mol Immunol. 2007;44:2481–2486
  24. Snyder GA, Colonna M, Sun PD. The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer. J Mol Biol. 2005;347:979–989
  25. Ryan EJ, Marshall AJ, Magaletti D, et al. Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. J Immunol. 2002;169:5638–5648
  26. Dakappagari N, Maruyama T, Renshaw M, et al. Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses. J Immunol. 2006;176:426–440
  27. Thomas TC, Rollins SA, Rother RP, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol. 1996;33:1389–1401
  28. Geijtenbeek TB, van Kooyk Y, Van Vliet SJ, Renes MH, Raymakers RA, Figdor CG. High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. Blood. 1999;94:754–764
  29. Daniels MA, Hogquist KA, Jameson SC. Sweet ‘n’ sour: the impact of differential glycosylation on T cell responses. Nat Immunol. 2002;3:903–910
  30. van Dongen JJ, Quertermous T, Bartram CR, et al. T cell receptor-CD3 complex during early T cell differentiation. Analysis of immature T cell acute lymphoblastic leukemias (T-ALL) at DNA, RNA, and cell membrane level. J Immunol. 1987;138:1260–1269
  31. van Gisbergen KP, Aarnoudse CA, Meijer GA, Geijtenbeek TB, van Kooyk Y. Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin. Cancer Res. 2005;65:5935–5944
  32. Maynadie M, Campos L, Moskovtchenko P, et al. Heterogenous expression of CD15 in acute lymphoblastic leukemia: a study of ten anti-CD15 monoclonal antibodies in 158 patients. Leuk Lymphoma. 1997;25:135–143
  33. Appelmelk BJ, Van DI, Van Vliet SJ, Vandenbroucke-Grauls CM, Geijtenbeek TB, van Kooyk Y. Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells. J Immunol. 2003;170:1635–1639
  34. Benharroch D, Dima E, Levy A, et al. Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease. Leuk Lymphoma. 2000;39:185–194
  35. Lavabre-Bertrand T, Duperray C, Brunet C, et al. Quantification of CD24 and CD45 antigens in parallel allows a precise determination of B-cell maturation stages: relevance for the study of B-cell neoplasias. Leukemia. 1994;8:402–408
  36. Goochee CF, Monica T. Environmental effects on protein glycosylation. Biotechnology. 1990;8:421–427
  37. Luczynski W, Stasiak-Barmuta A, Ilendo E, et al. Low expression of costimulatory molecules and mRNA for cytokines are important mechanisms of immunosuppression in acute lymphoblastic leukemia in children?. Neoplasma. 2006;53:301–304
  38. Yotnda P, Mintz P, Grigoriadou K, Lemonnier F, Vilmer E, Langlade-Demoyen P. Analysis of T-cell defects in the specific immune response against acute lymphoblastic leukemia cells. Exp Hematol. 1999;27:1375–1383
  39. Ebata K, Shimizu Y, Nakayama Y, et al. Immature NK cells suppress dendritic cell functions during the development of leukemia in a mouse model. J Immunol. 2006;176:4113–4124
  40. Fricke I, Gabrilovich DI. Dendritic cells and tumor microenvironment: a dangerous liaison. Immunol Invest. 2006;35:459–483
  41. Geijtenbeek TB, Van Vliet SJ, Engering A, 't Hart BA, van Kooyk Y. Self- and nonself-recognition by C-type lectins on dendritic cells. Annu Rev Immunol. 2004;22:33–54
  42. Bergman MP, Engering A, Smits HH, et al. Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN. J Exp Med. 2004;200:979–990
  43. Geijtenbeek TB, Van Vliet SJ, Koppel EA, et al. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med. 2003;197:7–17
  44. Lai WK, Sun PJ, Zhang J, et al. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am J Pathol. 2006;169:200–208

PII: S0301-472X(08)00069-6

doi: 10.1016/j.exphem.2008.02.003

Experimental Hematology
Volume 36, Issue 7 , Pages 860-870 , July 2008