Experimental Hematology
Volume 36, Issue 7 , Pages 807-815 , July 2008

Effects of GM-CSF gene transfer using silica-nanoparticles as a vehicle on white blood cell production in dogs

  • Eun Wha Choi

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science
    • Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Il Seob Shin

      Affiliations

    • Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Young Jin Chae

      Affiliations

    • Department of Veterinary Biochemistry, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Hye Cheong Koo

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science
    • Department of Veterinary Microbiology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Jong Hwa Lee

      Affiliations

    • Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Tae Ho Chung

      Affiliations

    • Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Yong Ho Park

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science
    • Department of Veterinary Microbiology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Dae Yong Kim

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science
    • Department of Veterinary Pathology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Cheol Yong Hwang

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science
    • Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Chang Woo Lee

      Affiliations

    • Department of Veterinary Clinical Pathology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • ,
  • Hwa Young Youn

      Affiliations

    • KRF Zoonotic Disease Priority Research Institute, Research Institute of Veterinary Science
    • Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, Korea
    • Corresponding Author InformationOffprint requests to: Hwa Young Youn, D.V.M., Ph.D., Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Sillim 9-dong, Gwanak-gu, (151–742), Seoul, Korea

Received 15 September 2007 ,Revised 21 January 2008 ,Accepted 23 January 2008.

References 

  1. Ogilvie GK, Obradovich JE, Cooper MF, Walters LM, Salman MD, Boone TC. Use of recombinant canine granulocyte colony-stimulating factor to decrease myelosuppression associated with the administration of mitoxantrone in the dog. J Vet Intern Med. 1992;6:44–47
  2. Quesniaux VFJ, Jones TC. Granulocyte-macrophage colony stimulating factor. In:  Thomson AW editors. The Cytokine Handbook. 3rd ed.. London: Academic Press; 1998;p. 637–659
  3. Shin IS, Nam MJ, Park SJ, Youn HY, Han HR. Cloning of canine GM-CSF and SCF genes. J Vet Sci. 2001;2:159–166
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  7. Bharali DJ, Klejbor I, Stachowiak EK, et al. Organically modified silica-nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci U S A. 2005;102:11539–11544
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  14. Lloyd AR, Oppenheim JJ. Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol Today. 1992;13:169–172
  15. Gosselin EJ, Wardwell K, Rigby WF, Guyre PM. Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3. J Immunol. 1993;151:1482–1490
  16. Okuda K, Neely BC, David CS. Expression of H-2 and Ia antigens on mouse peritoneal neutrophils. Transplantation. 1979;28:354–356
  17. Fitzgerald JE, Sonis ST, Rodrick ML, Wilson RE. Interaction of Ia antigen-bearing polymorphonuclear leukocytes and murine splenocytes. Inflammation. 1983;7:25–33
  18. Gangi E, Vasu C, Cheatem D, Prabhakar BS. IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. J Immunol. 2005;174:7006–7013
  19. Keller P, Smalling R. Granulocyte colony stimulating factor: animal studies for risk assessment. Int Rev Exp Pathol. 1993;34:173–188
  20. Antman KS, Griffin JD, Elias A, et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med. 1988;319:593–598

PII: S0301-472X(08)00043-X

doi: 10.1016/j.exphem.2008.01.007

Experimental Hematology
Volume 36, Issue 7 , Pages 807-815 , July 2008

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