Experimental Hematology
Volume 36, Issue 5 , Pages 533-534 , May 2008

Role of the tumor necrosis factor ligand APRIL in Hodgkin's lymphoma: a retrospective study including 107 cases

  • Bertrand Huard

      Affiliations

    • Corresponding Author InformationOffprint requests to: Bertrand Huard, Ph.D., Department of Pathology-Immunology, University Medical Center, Rue Michel Servet 1, 1211 Geneva 4, Switzerland

References 

  1. Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol. 2005;17:282–289
  2. Planelles L, Carvalho-Pinto CE, Hardenberg G, et al. APRIL promotes B-1 cell-associated neoplasm. Cancer Cell. 2004;6:399–408
  3. Jelinek DF, Darce JR. Human B lymphocyte malignancies: exploitation of BLyS and APRIL and their receptors. Curr Dir Autoimmun. 2005;8:266–288
  4. Planelles L, Castillo-Gutierrez S, Medema JP, Morales-Luque A, Merle-Beral H, Hahne M. APRIL but not BLyS serum levels are increased in chronic lymphocytic leukemia: prognostic relevance of APRIL for survival. Haematologica. 2007;92:1284–1285
  5. Schwaller J, Schneider P, Mhawech-Fauceglia P, et al. Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. Blood. 2007;109:331–338
  6. Chiu A, Xu W, He B, et al. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood. 2007;109:729–739
  7. Tzankov A, Zimpfer A, Went P, et al. Aberrant expression of cell cycle regulators in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma. Mod Pathol. 2005;18:90–96
  8. Schwaller J, Went P, Matthes T, et al. Paracrine promotion of tumor development by the TNF ligand APRIL in Hodgkin's disease. Leukemia. 2007;21:1324–1327
  9. Zielinski CC, Preis P, Aiginger P, Eibl MM. Acute-phase-proteins and parameters of humoral immunity in patients with advanced Hodgkin's disease. J Cancer Res Clin Oncol. 1985;110:65–70

PII: S0301-472X(08)00004-0

doi: 10.1016/j.exphem.2007.12.017

Experimental Hematology
Volume 36, Issue 5 , Pages 533-534 , May 2008

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