« Previous
Next »
Experimental Hematology
Volume 35, Issue 12
, Pages 1793-1800
, December 2007
P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors
References
- . The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett. 2006;580:998–1009
- . P-glycoprotein: from genomics to mechanism. Oncogene. 2003;22:7468–7485
- . Targeting multidrug resistance in cancer. Nat Rev Drug Discov. 2006;5:219–234
- . Multidrug resistance and the role of P-glycoprotein knockout mice. Eur J Cancer. 1995;31A:1295–1298
- . Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor. Eur J Nutr. 2004;43:336–343
- . Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay. Cytometry A. 2003;53:67–78
- . Regulation of the mevalonate pathway. Nature. 1990;343:425–430
- . Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells. Blood. 1994;84:2689–2698
- . Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. Blood. 2003;101:3628–3634
- . Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. Blood. 2004;104:1816–1824
- Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high dose Ara-C: a Phase 1 study. Blood. 2007;109:2999–3006
- . The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proc Natl Acad Sci U S A. 2002;99:10347–10352
- . Role of multidrug resistance p-glycoproteins in cholesterol esterification. J Biol Chem. 1997;272:1026–1031
- . Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. J Biol Chem. 1999;274:6979–6991
- . Cholesterol homeostasis. Modulation by amphiphiles. J Biol Chem. 1994;269:29371–29374
- Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem. 2000;275:15122–15127
- . The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med. 2001;7:584–590
- Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia. 1995;9:799–807
- . Isolation and analysis of lipoproteins secreted by rat liver hepatocytes. Biochim Biophys Acta. 1984;792:39–47
- Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells. Biochemistry. 2005;44:4499–4509
- . Flow cytometric measurement of functional and phenotypic p-glycoprotein. In: Blumenthal RD editors. Chemosensitivity. Totowa: Humana Press; 2005;p. 167–181
- . Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript. Genes Chromosomes Cancer. 1999;26:355–365
- Use of standardised flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia. Br J Haematol. 1999;104:307–312
- . Flow cytometric chemosensitivity analysis of blasts from patients with acute myeloblastic leukemia and myelodysplastic syndromes: the use of 7AAD with antibodies to CD45 or CD34. Cytometry. 1999;37:308–313
- . Differential expression and activity of phosphatases and protein kinases in adriamycin sensitive and resistant human breast cancer MCF-7 cells. Int J Oncol. 1998;13:79–84
- . Effects of ion gradients on H+ transport mediated by human MDR 1 protein. Biochemistry. 1999;38:4227–4234
- Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay. Anal Biochem. 1996;236:338–343
- . Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res. 1991;51:3602–3609
- Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A southwest oncology group study. Blood. 1997;89:3323–3329
- Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study. Blood. 1999;94:1086–1099
- . Role of multidrug resistance p-glycoproteins in cholesterol biosynthesis. J Biol Chem. 1996;271:2634–2640
- . Transport of cholesterol from the endoplamic reticulum to the plasma membrane is constitutive in CaCo-2 cells and differs from the transport of plasma membrane cholesterol to the endoplasmic reticulum. J Lipid Res. 1998;39:333–343
- . Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis. J Lipid Res. 2006;47:51–58
- MDR1, cholesterol esterification and cell growth: a comparative study in normal and multidrug-resistant KB cell lines. Cell Mol Life Sci. 2000;57:1094–1102
- Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells. Biochim Biophys Acta. 2006;1760:1866–1873
- . HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells. Nat Med. 1996;2:326–333
- Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach. Blood. 1999;93:1308–1318
- Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin. Leukemia. 2000;14:1444–1450
PII: S0301-472X(07)00457-2
doi: 10.1016/j.exphem.2007.07.017
© 2007 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Experimental Hematology
Volume 35, Issue 12
, Pages 1793-1800
, December 2007
