Experimental Hematology
Volume 35, Issue 12 , Pages 1847-1857 , December 2007

Bone marrow–derived CD8α+TCR cells that facilitate allogeneic bone marrow transplantation are a mixed population of lymphoid and myeloid progenitors

  • Nupur N. Gangopadhyay

      Affiliations

    • Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, Pa., USA
    • Corresponding Author InformationOffprint requests to: Nupur N. Gangopadhyay, Ph.D., University of Pittsburgh, University of Pittsburgh Cancer Institute, HCC 2.18B, Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213
  • ,
  • Rosemary A. Hoffman

      Affiliations

    • Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pa., USA
  • ,
  • Hongmei Shen

      Affiliations

    • Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pa., USA
  • ,
  • James D. Luketich

      Affiliations

    • Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, Pa., USA
  • ,
  • Matthew J. Schuchert

      Affiliations

    • Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, Pa., USA

Received 23 May 2007 ,Revised 12 July 2007 ,Accepted 16 July 2007.

References 

  1. Billingham RE, Brent L, Medawar PB. ‘Actively acquired tolerance’ of foreign cells. 1953. Transplantation. 2003;76:1409–1412
  2. Nakao A, Toyokawa H, Kimizuka K, et al. Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism. Blood. 2006;108:1413–1420
  3. Anversa P, Leri A, Kajstura J. Cardiac regeneration. J Am Coll Cardiol. 2006;47:1769–1776
  4. Atala A. Recent developments in tissue engineering and regenerative medicine. Curr Opin Pediatr. 2006;18:167–171
  5. Shlomchik WD. Graft-versus-host disease. Nat Rev. 2007;7:340–352
  6. Morris ES, MacDonald KP, Hill GR. Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?. Blood. 2006;107:3430–3435
  7. Martin PJ. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans. J Exp Med. 1993;178:703–712
  8. Fowler DH, Whitfield B, Livingston M, Chrobak P, Gress RE. Non-host-reactive donor CD8+ T cells of Tc2 phenotype potently inhibit marrow graft rejection. Blood. 1998;91:4045–4050
  9. Cao TM, Shizuru JA, Wong RM, et al. Engraftment and survival following reduced-intensity allogeneic peripheral blood hematopoietic cell transplantation is affected by CD8+ T-cell dose. Blood. 2005;105:2300–2306
  10. Kim DH, Won DI, Lee NY, Sohn SK, Suh JS, Lee KB. Non-CD34+ cells, especially CD8+ cytotoxic T cells and CD56+ natural killer cells, rather than CD34 cells, predict early engraftment and better transplantation outcomes in patients with hematologic malignancies after allogeneic peripheral stem cell transplantation. Biol Blood Marrow Transplant. 2006;12:719–728
  11. Kaufman CL, Colson YL, Wren SM, Watkins S, Simmons RL, Ildstad ST. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood. 1994;84:2436–2446
  12. Schuchert MJ, Wright RD, Colson YL. Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment. Nat Med. 2000;6:904–909
  13. Fugier-Vivier IJ, Rezzoug F, Huang Y, et al. Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J Exp Med. 2005;201:373–383
  14. Zakrzewski JL, Kochman AA, Lu SX, et al. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat Med. 2006;12:1039–1047
  15. Gangopadhyay NN, Shen H, Landreneau R, Luketich JD, Schuchert MJ. Isolation and tracking of a rare lymphoid progenitor cell which facilitates bone marrow transplantation in mice. J Immunol Methods. 2004;292:73–81
  16. Schmitt TM, Zuniga-Pflucker JC. T-cell development, doing it in a dish. Immunol Rev. 2006;209:95–102
  17. Plum J, De Smedt M, Leclercq G, Verhasselt B, Vandekerckhove B. Interleukin-7 is a critical growth factor in early human T-cell development. Blood. 1996;88:4239–4245
  18. Balciunaite G, Ceredig R, Fehling HJ, Zuniga-Pflucker JC, Rolink AG. The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Eur J Immunol. 2005;35:1292–1300
  19. Trop S, Rhodes M, Wiest DL, Hugo P, Zuniga-Pflucker JC. Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCR. J Immunol. 2000;165:5566–5572
  20. Van Leeuwen JE, Kearse KP. The related molecular chaperones calnexin and calreticulin differentially associate with nascent T cell antigen receptor proteins within the endoplasmic reticulum. J Biol Chem. 1996;271:25345–25349
  21. Schmitt TM, de Pooter RF, Gronski MA, Cho SK, Ohashi PS, Zuniga-Pflucker JC. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat Immunol. 2004;5:410–417
  22. Rafi-Janajreh AQ, Nagarkatti PS, Nagarkatti M. Role of CD44 in CTL and NK cell activity. Front Biosci. 1998;3:d665–d671
  23. Termeer C, Averbeck M, Hara H, et al. Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis. Immunology. 2003;109:32–40
  24. Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001;153:1277–1286
  25. Dutton RW, Bradley LM, Swain SL. T cell memory. Ann Rev Immunol. 1998;16:201–223
  26. Maeda Y, Tawara I, Teshima T, et al. Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease. Exp Hematol. 2007;35:274–286
  27. Perry SS, Welner RS, Kouro T, Kincade PW, Sun XH. Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential. J Immunol. 2006;177:2880–2887
  28. Klein F, Feldhahn N, Lee S, et al. T lymphoid differentiation in human bone marrow. Proc Natl Acad Sci U S A. 2003;100:6747–6752
  29. Lai AY, Kondo M. Identification of a bone marrow precursor of the earliest thymocytes in adult mouse. Proc Natl Acad Sci U S A. 2007;104:6311–6316
  30. Umland O, Mwangi WN, Anderson BM, Walker JC, Petrie HT. The blood contains multiple distinct progenitor populations with clonogenic B and T lineage potential. J Immunol. 2007;178:4147–4152
  31. Rothenberg EV, Taghon T. Molecular genetics of T cell development. Ann Rev Immunol. 2005;23:601–649
  32. Huang Y, Kucia M, Rezzoug F, et al. Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance. Stem Cells. 2006;24:936–948
  33. Robertson P, Means TK, Luster AD, Scadden DT. CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus. Exp Hematol. 2006;34:308–319
  34. Ray N, Doms RW. HIV-1 coreceptors and their inhibitors. Curr Topics Microbiol Immunol. 2006;303:97–120
  35. Ara T, Itoi M, Kawabata K, et al. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol. 2003;170:4649–4655
  36. Efroni S, Harel D, Cohen IR. Emergent dynamics of thymocyte development and lineage determination. PLoS Comput Biol. 2007;3:e13
  37. Majka M, Ratajczak MZ. Biological role of the CXCR4-SDF-1 axis in normal human hematopoietic cells. Methods Mol Biol. 2006;332:103–114
  38. Foss DL, Donskoy E, Goldschneider I. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J Exp Med. 2001;193:365–374
  39. Prockop SE, Petrie HT. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J Immunol. 2004;173:1604–1611
  40. Chau LA, Rohekar S, Wang JJ, et al. Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients. Clin Exp Immunol. 2002;127:43–52

PII: S0301-472X(07)00438-9

doi: 10.1016/j.exphem.2007.07.016

Experimental Hematology
Volume 35, Issue 12 , Pages 1847-1857 , December 2007