Experimental Hematology
Volume 35, Issue 4 , Pages 572-578 , April 2007

RTP801 is a novel retinoic acid–responsive gene associated with myeloid differentiation

  • Sigal Gery

      Affiliations

    • Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, Calif., USA
    • Corresponding Author InformationOffprint requests to: Sigal Gery, PhD, Cedars-Sinai Medical Center, Davis Bldg. 5066, 8700 Beverly Blvd., Los Angeles, CA 90048
    • These authors contributed equally to the manuscript.
  • ,
  • Dorothy J. Park

      Affiliations

    • Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, Calif., USA
    • These authors contributed equally to the manuscript.
  • ,
  • Peter T. Vuong

      Affiliations

    • Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, Calif., USA
  • ,
  • Renu K. Virk

      Affiliations

    • Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, Calif., USA
  • ,
  • Claudia I. Muller

      Affiliations

    • Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, Calif., USA
  • ,
  • Wolf-K. Hofmann

      Affiliations

    • Department of Hematology and Oncology and Transfusion Medicine, University Hospital “Benjamin Franklin,” Berlin, Germany
  • ,
  • H. Phillip Koeffler

      Affiliations

    • Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, Calif., USA

Received 24 November 2006 ,Revised 20 January 2007 ,Accepted 22 January 2007.

References 

  1. Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene. 2003;22:7305–7315
  2. Okuno M, Kojima S, Matsushima-Nishiwaki R, et al. Retinoids in cancer chemoprevention. Curr Cancer Drug Targets. 2004;4:285–298
  3. Gaines P, Berliner N. Retinoids in myelopoiesis. J Biol Regul Homeost Agents. 2003;17:46–65
  4. Idres N, Benoit G, Flexor MA, Lanotte M, Chabot GG. Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites. Cancer Res. 2001;61:700–705
  5. Dragnev KH, Petty WJ, Dmitrovsky E. Retinoid targets in cancer therapy and chemoprevention. Cancer Biol Ther. 2003;2(4 Suppl 1):S150–S156
  6. Soprano DR, Qin P, Soprano KJ. Retinoic acid receptors and cancers. Annu Rev Nutr. 2004;24:201–221
  7. Shoshani T, Faerman A, Mett I, et al. Identification of a novel hypoxia-inducible factor 1–responsive gene, RTP801, involved in apoptosis. Mol Cell Biol. 2002;22:2283–2293
  8. Ellisen LW, Ramsayer KD, Johannessen CM, et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell. 2002;10:995–1005
  9. Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW. Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem. 2003;278:27053–27058
  10. Brugarolas J, Lei K, Hurley RL, et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 2004;18:2893–2904
  11. Reiling JH, Hafen E. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev. 2004;18:2879–2892
  12. Corradetti MN, Inoki K, Guan KL. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005;280:9769–9772
  13. Schwarzer R, Tondera D, Arnold W, Giese K, Klippel A, Kaufmann J. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene. 2005;24:1138–1149
  14. Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol. 2005;25:5834–5845
  15. Gery S, Xie D, Yin D, et al. Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells. Clin Cancer Res. 2005;11:7243–7254
  16. Park DJ, Chumakov AM, Vuong PT, et al. CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. J Clin Invest. 1999;103:1399–1408
  17. Hofmann WK, de Vos S, Komor M, Hoelzer D, Wachsman W, Koeffler HP. Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood. 2002;100:3553–3560
  18. Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP. Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes. Blood. 2004;104:3911–3917
  19. Lin L, Stringfield TM, Shi X, Chen Y. Arsenite induces a cell stress response gene RTP801 through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer binding protein. Biochem J. 2005;392:93–102
  20. Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol. 2000;2:515–520
  21. Yoshimura K, Crystal RG. Transcriptional and posttranscriptional modulation of human neutrophil elastase gene expression. Blood. 1992;79:2733–2740
  22. Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926–1945
  23. Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005;37:19–24
  24. Weinmann M, Belka C, Plasswilm L. Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours. Onkologie. 2004;27:83–90
  25. Recher C, Beyne-Rauzy O, Demur C, et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood. 2005;105:2527–2534
  26. Witzig TE, Kaufmann SH. Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. Curr Treat Options Oncol. 2006;7:285–294
  27. Liu W, Guo M, Xu YB, et al. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood. 2006;107:698–707
  28. Lane AA, Ley TJ. Neutrophil elastase cleaves PML-RARα and is important for the development of acute promyelocytic leukemia in mice. Cell. 2003;115:305–318
  29. Duan Z, Li FQ, Wechsler J, et al. A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia. Mol Cell Biol. 2004;24:58–70

PII: S0301-472X(07)00061-6

doi: 10.1016/j.exphem.2007.01.049

Experimental Hematology
Volume 35, Issue 4 , Pages 572-578 , April 2007