Experimental Hematology
Volume 34, Issue 11 , Pages 1553-1562, November 2006

Cloning and characterizing mutated human stromal cell-derived factor-1 (SDF-1): C-terminal α-helix of SDF-1α plays a critical role in CXCR4 activation and signaling, but not in CXCR4 binding affinity

  • Yi Tan

      Affiliations

    • Department of Clinical Pharmacology, Pharmacy School of Jinan University, Guangzhou, China
    • College of Bioengineering, Key Laboratory for Biomechanics and Tissue Engineering of the State Ministry of Education, Chongqing University, Chongqing, China
    • Bioengineering Medicine Research Center of the State Ministry of Education, Jinan University, Guangzhou, China
    • School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou, China
    • ,
  • Jun Du

      Affiliations

    • School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
    • ,
  • Shaoxi Cai

      Affiliations

    • College of Bioengineering, Key Laboratory for Biomechanics and Tissue Engineering of the State Ministry of Education, Chongqing University, Chongqing, China
    • ,
  • Xiaokun Li

      Affiliations

    • Bioengineering Medicine Research Center of the State Ministry of Education, Jinan University, Guangzhou, China
    • School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou, China
    • ,
  • Weifeng Ma

      Affiliations

    • College of Bioengineering, Key Laboratory for Biomechanics and Tissue Engineering of the State Ministry of Education, Chongqing University, Chongqing, China
    • ,
  • Zhigang Guo

      Affiliations

    • College of Bioengineering, Key Laboratory for Biomechanics and Tissue Engineering of the State Ministry of Education, Chongqing University, Chongqing, China
    • ,
  • Hongyuan Chen

      Affiliations

    • College of Bioengineering, Key Laboratory for Biomechanics and Tissue Engineering of the State Ministry of Education, Chongqing University, Chongqing, China
    • ,
  • Zhifeng Huang

      Affiliations

    • School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou, China
    • ,
  • Jian Xiao

      Affiliations

    • Department of Clinical Pharmacology, Pharmacy School of Jinan University, Guangzhou, China
    • School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou, China
    • ,
  • Lu Cai

      Affiliations

    • School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou, China
    • Departments of Medicine, Radiation Oncology and Pharmacology and Toxicology, University of Louisville, Ky., USA
    • Corresponding Author InformationOffprint requests to: Lu Cai, M.D., Ph.D., Departments of Medicine, Radiation Oncology and Pharmacology and Toxicology, University of Louisville, 511 South Floyd Street, MDR 533, Louisville, KY 40202
    • ,
  • Shaohui Cai

      Affiliations

    • Department of Clinical Pharmacology, Pharmacy School of Jinan University, Guangzhou, China
    • Corresponding Author InformationOffprint requests to: Shaohui Cai, M.D., Ph.D., Departments of Medicine, Radiation Oncology and Pharmacology and Toxicology, University of Louisville, 511 South Floyd Street, MDR 533, Louisville, KY 40202

Received 9 June 2006; received in revised form 28 June 2006; accepted 10 July 2006.

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PII: S0301-472X(06)00430-9

doi:10.1016/j.exphem.2006.07.001

Experimental Hematology
Volume 34, Issue 11 , Pages 1553-1562, November 2006

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