Experimental Hematology
Volume 34, Issue 11 , Pages 1480-1489 , November 2006

A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia

  • Ming-Jer Huang

      Affiliations

    • Department of Medicine, MacKay Memorial Hospital, Taipei, Taiwan
    • ,
  • Yuan-chih Cheng

      Affiliations

    • Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Chien-Ru Liu

      Affiliations

    • Department of Radiation Oncology, Taipei Municipal Hospital, Ren-Ai Branch, Taipei, Taiwan
    • ,
  • Shufan Lin

      Affiliations

    • Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • H. Eugene Liu

      Affiliations

    • Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
    • Department of Internal Medicine, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan
    • Corresponding Author InformationOffprint requests to: H. Eugene Liu, M.D., Ph.D., Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 2F, 30-1, Jinhua St, Zhongchen District, Taipei, Taiwan, 100

References 

  1. Pelengaris S, Khan M. The many faces of c-MYC. Arch Biochem Biophys. 2003;416:129–136
  2. Dang CV. c-Myc target genes involved in cell growth, apoptosis and metabolism. Mol Cell Biol. 1999;19:1–11
  3. Harris AW, Pinkert CA, Crawford M, Langdon WY, Brinster RL, Adams JM. The E mu-myc transgenic mouse. a model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med. 1988;167:353–371
  4. Rothberg PG, Erisman MD, Diehl RE, Rovigatti UG, Astrin SM. Structure and expression of the oncogene c-myc in fresh tumor material from patients with hematopoietic malignancies. Mol Cell Biol. 1984;4:1096–1103
  5. Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes. Cell. 1992;70:901–910
  6. Muellar-Tidow C, Steffen B, Cauvet T, et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol. 2004;24:2890–2904
  7. Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532–1542
  8. Luo H, O'Neal J, Kreisel F, Le Beau MM, Tomasson MH. c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood. 2005;106:2542–2561
  9. Felsher DW, Bishop JM. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell. 1999;4:199–207
  10. Jain M, Arvanitis C, Chu K, et al. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science. 2002;297:102–104
  11. O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic phase myeloid leukemia. N Engl J Med. 2003;348:994–1004
  12. Mo H, Henriksson M. Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation. Proc Natl Acad Sci U S A. 2006;103:6344–6349
  13. Berg T, Cohen SB, Desharnais J, et al. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc Natl Acad Sci U S A. 2002;99:3830–3835
  14. Yin X, Giap C, Lazo JS, Prochownik EV. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene. 2003;22:6151–6159
  15. Sommer A, Bousset K, Kremmer E, Austen M, Luescher B. Identification and characterization of specific DNA-binding complexes containing members of the myc/Max/mad network of transcriptional regulators. J Biol Chem. 1998;273:6632–6642
  16. Krishan A. Rapid flow cytofluorometric analysis of cell cycle by propidium iodide staining. J Cell Biol. 1975;66:188
  17. Kizaki M, Matsushita H, Takayama N, et al. Establishment and characterization of a novel acute promyelocytic leukemia cell line (UF-1) with retinoic acid-resistant features. Blood. 1996;88:1824–1833
  18. Ginzinger DG. Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream. Exp Hematol. 2002;30:503–512
  19. Xu D, Popov N, Hou M, et al. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci U S A. 2001;98:3826–3831
  20. Mukherjee S, Conrad SE. c-Myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer. J Biol Chem. 2005;280:17617–17625
  21. Obaya AJ, Kotenko I, Cole MD, Sedivy JM. The proto-oncogene c-myc acts through cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G1 phase progression. J Biol Chem. 2002;277:31263–31269
  22. Seoane J, Le HV, Massague J. Myc suppression of the p21(Cip1) CDK inhibitor influences the outcome of the p53 response to DNA damage. Nature. 2002;419:729–734
  23. Bouchard C, Thieke K, Maier A, et al. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J. 1999;18:5321–5333
  24. Friedman AD. Transcriptional regulation of granulocytic and monocytic development. Oncogene. 2002;21:3377–3390
  25. Wang Q, Salman H, Danilenko M, Studzinski GP. Cooperation between antioxidants and 1.25-dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr1 pathway. J Cell Physiol. 2005;204:964–974
  26. Friedman AD, Keefer JR, Kummalue T, Liu H, Wang QF, Cleaves R. Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha. Blood Cells Mol Dis. 2003;31:338–341
  27. Rekhtman N, Choe KS, Matushansky I, Murray S, Stopka T, Skoultchi AI. PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation. Mol Cell Biol. 2003;23:7460–7474
  28. Roussel MF, Theodoras AM, Pagano M, Sherr CJ. Rescue of defective mitogenic signaling by D-type cyclins. Proc Natl Acad Sci U S A. 1995;92:6837–6841
  29. Gartel AL, Ye X, Goufman E, et al. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A. 2001;98:4510–4515
  30. Danova M, Giordano M, Mazzini G, Riccardi A. Expression of p53 protein during the cell cycle measured by flow cytometry in human leukemia. Leuk Res. 1990;14:417–422
  31. Song XD, Sheppard HM, Norman AW, Liu X. Mitogen-activated protein kinase in involved in the degradation of p53 in the bryostatin-1-induced differentiation of the acute promyelocytic leukemia NB4 cell line. J Biol Chem. 1999;274:1677–1682
  32. Blyth K, Terry A, O'Hara M, et al. Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene. 1995;10:1717–1723
  33. Ho JSL, Ma W, Mao DYL, Benchimol S. p53-dependent transcriptional repression of c-myc in required fro G1 cell cycle arrest. Mol Cell Biol. 2005;25:7423–7431
  34. Valera A, Pujol A, Gregori X, Riu E, Visa J, Bosch F. Evidence of transgenic mice that myc regulate hepatic glycolysis. FASEB J. 1995;9:1067–1078
  35. Shim H, Chun YS, Lewis BC, Dang CV. A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc Natl Acad Sci U S A. 1998;95:1511–1516
  36. Lewis BC, Prescott JE, Campbell SE, Shim H, Orlowski RZ, Dang CV. Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A. Cancer Res. 2000;60:6178–6183
  37. Reitsma PH, Rothberg PG, Astrin SM, et al. Regulation of myc gene expression in HL-60 leukemia cells by a vitamin D metabolite. Nature. 1983;306:492–494
  38. Wu S, Cetinkaya C, Munoz-Alonso MJ, et al. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene. 2003;22:351–360
  39. Li ZR, Hromchak R, Mudipalli A, Bloch A. Tumor suppressor proteins as regulators of cell differentiation. Cancer Res. 1998;58:4282–4287
  40. Pan Z, Hetherington CJ, Zhang DE. CCAAT/enhancer-binding protein activates the CD14 promoter and mediate transforming growth factor beta signaling in monocyte development. J Biol Chem. 1999;274:23242–23248

 M.-J. Huang and Y.-C. Cheng contributed equally to this work.

PII: S0301-472X(06)00428-0

doi: 10.1016/j.exphem.2006.06.019

Experimental Hematology
Volume 34, Issue 11 , Pages 1480-1489 , November 2006

Article Tools

* Image Usage & Resolution