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Experimental Hematology
Volume 34, Issue 10
, Pages 1303-1311
, October 2006
Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia
References
- . Anemia. Not just an innocent bystander?. Arch Intern Med. 2003;163:1400–1404
- . Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023
- Small peptides as potent mimetics of the protein hormone erythropoietin. Science. 1996;273:458–464
- Wrighton NC, Balasubramanian P, Barbone FP, et al. Increased potency of an erythropoietin peptide mimetic through covalent dimerization. Nat Biotechnol. 1997 Nov;15:1261–1265.
- . Effect of pegylation on pharmaceuticals. Nat Rev. 2003;2:214–221
- . Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers. J Biol Chem. 1998;263:15064–15070
- . Antibody-mediated pure red cell aplasia (PRCA): epidemiology, immunogenicity and risks. Nephrol Dial Transplant. 2005;20:9–15
- Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med. 2002;346:469–475
- Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. Blood. 1993;82(2):456–464
- . Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63
- Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. Blood. 1999;94:1568–1577
- Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood. 2003;101:3436–3443
- . Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol. 2005;15:146–155
- . Effect of purified recombinant human erythropoietin on anemia in rats with experimental renal failure induced by five-sixth nephrectomy. Biotherapy. 1990;2:77–85
- . Nitric oxide metabolism in erythropoietin-induced hypertension. Effect of calcium channel blockade. Hypertension. 1998;32:724–729
- Pharmacokinetic properties of five polyethylene glycol conjugates of interferon alfa-2a. Antivir Ther. 1999;4:27
- Improved pharmacokinetic properties of a polyethylene glycol–modified form of interferon-β-1a with preserved in vitro bioactivity. J Pharmacol Exp Ther. 2001;297:1059–1066
- . Use of peginterferon alfa-2a (40 KD) (Pegasys®) for the treatment of hepatitis C. Adv Drug Deliv Rev. 2002;54:571–586
- . Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. Exp Hematol. 2003;31:290–299
- . Hematology of nonhuman primates. Chapter 176. In: Feldman BF, Zinkl JG, Jain NC editor. Schalm's Veterinary Hematology. 5th ed.. Philadelphia: Lippincott Williams & Wilkins; 2000;p. 1133–1144
- . Hematology of the rat (Rattus norvegicus). Chapter 189. In: Feldman BF, Zinkl JG, Jain NC editor. Schalm's Veterinary Hematology. 5th ed.. Philadelphia: Lippincott Williams & Wilkins; 2000;p. 1210–1224
- Hematide™, a synthetic peptide-based erythropoiesis stimulating agent (ESA), demonstrates dose dependent activity and is well tolerated in a Phase 1 single dose, dose escalating study in Normal Healthy Volunteers (NHV). J Clin Oncol. 2005;23:16S, Abstract 773s
PII: S0301-472X(06)00329-8
doi: 10.1016/j.exphem.2006.05.012
© 2006 International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.
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Experimental Hematology
Volume 34, Issue 10
, Pages 1303-1311
, October 2006
