Experimental Hematology
Volume 34, Issue 10 , Pages 1312-1322 , October 2006

Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia

  • Charalampos Pontikoglou

      Affiliations

    • Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece
    • ,
  • George Liapakis

      Affiliations

    • Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece
    • ,
  • Katerina Pyrovolaki

      Affiliations

    • Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece
    • ,
  • Marios Papadakis

      Affiliations

    • Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece
    • ,
  • Juergen Bux

      Affiliations

    • Deutsches Rotes Kreuz Blood Service West, Hagen, Germany
    • ,
  • George D. Eliopoulos

      Affiliations

    • Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece
    • ,
  • Helen A. Papadaki

      Affiliations

    • Department of Hematology of the University of Crete School of Medicine, Heraklion, Crete, Greece
    • Corresponding Author InformationOffprint requests to: Helen A. Papadaki, M.D., Ph.D., Department of Hematology, University Hospital of Heraklion, P.O. Box 1352, Heraklion, Crete, Greece

Received 22 December 2005 ,Revised 12 May 2006 ,Accepted 12 May 2006.

References 

  1. Kyle RA, Linman JW. Chronic idiopathic neutropenia. A newly recognized entity?. N Engl J Med. 1968;279:1015–1019
  2. Dale DC, Guerry D, Wewerka JR, Bull JM, Chusid MJ. Chronic neutropenia. Medicine (Baltimore). 1979;58:128–144
  3. Haddy TB, Rana SR, Castro O. Benign ethnic neutropenia: what is a normal absolute neutrophil count?. J Lab Clin Med. 1999;133:15–22
  4. Papadaki HA, Palmblad J, Eliopoulos GD. Non-immune chronic idiopathic neutropenia of adult: an overview. Eur J Haematol. 2001;67:35–44
  5. Kyle RA. Natural history of chronic idiopathic neutropenia. N Engl J Med. 1980;302:908–909
  6. Papadaki HA, Eliopoulos GD, Coulocheri SA, Spyropoulou M, Stavropoulos-Giokas C. Increased frequency of HLA-DRB1∗1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. Blood. 2001;97:580–581
  7. Eliopoulos GD, Meletis J, Fessas P, Anagnou NP. Defective CSA-dependent granulopoiesis in patients with chronic neutropenia. Haematologia. 1990;23:101–109
  8. Papadaki HA, Chatzivassili A, Stefanaki K, Koumaki V, Kanavaros P, Eliopoulos GD. Morphologically defined myeloid cell compartments, lymphocyte subpopulations, and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults. Ann Hematol. 2000;79:563–570
  9. Papadaki HA, Eliopoulos AG, Kosteas T, et al. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood. 2003;101:2591–2600
  10. Papadaki HA, Eliopoulos GD. The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle. 2003;2:447–451
  11. Koumaki V, Papadaki HA, Stefanaki K, et al. Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia. Ann Hematol. 2003;82:641–645
  12. Papadaki HA, Giouremou K, Eliopoulos GD. Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-β1 by bone marrow stromal cells. Eur J Haematol. 1999;63:154–162
  13. Papadaki HA, Stamatopoulos K, Damianaki A, et al. Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia. Br J Haematol. 2005;128:863–867
  14. Papadaki HA, Eliopoulos DG, Valatas V, Eliopoulos GD. Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults. Ann Hematol. 2001;80:195–200
  15. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood. 1992;80:1639–1647
  16. Rusten LS, Jacobsen SE. Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors. Blood. 1995;85:989–996
  17. Dai CH, Price JO, Brunner T, Krantz SB. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood. 1998;91:1235–1242
  18. Palmblad J, Papadaki HA, Eliopoulos GD. Acute and chronic neutropenias. What is new?. J Intern Med. 2001;250:476–491
  19. Miller CB, Jones RJ, Piantadosi S, Abeloff MD, Spivak JL. Decreased erythropoietin response in patients with anemia of cancer. N Engl J Med. 1990;322:1689–1692
  20. Papadaki HA, Kritikos HD, Valatas V, Boumpas DT, Eliopoulos GD. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti–tumor necrosis factor-alpha antibody therapy. Blood. 2002;100:474–482
  21. Coutinho LH, Gilleece MH, De Wynter EA, Will A, Testa NG. Clonal and long-term cultures using human bone marrow. In:  Testa NG,  Molineux G editor. Haemopoiesis. A practical approach. Oxford: Oxford University Press; 1993;p. 75–106
  22. Philpott NJ, Turner AJ, Scopes J, et al. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood. 1996;87:2244–2251
  23. Tennant GB, Walsh V, Truran LN, Edwards P, Mills KI, Burnett AK. Abnormalities of adherent layers grown from bone marrow of patients with myelodysplasia. Br J Haematol. 2000;111:853–862
  24. Charbord P. Mediators involved in the control of hematopoiesis by the microenvironment. In:  Zon L editors. Hematopoiesis. A developmental approach. New York: Oxford University Press, Inc.; 2001;p. 702–717
  25. Papadaki HA, Kritikos HD, Gemetzi C, et al. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha–mediated effect. Blood. 2002;99:1610–1619
  26. Loken MR, Shah VO, Dattilio KL, Civin CI. Flow cytometric analysis of human bone marrow: I. Normal erythroid development. Blood. 1987;69:255–263
  27. Greenwalt DE, Lipsky RH, Ockenhouse CF, Ikeda H, Tandon NN, Jamieson GA. Membrane glycoprotein CD36: A review of its roles in adherence, signal transduction, and transfusion medicine. Blood. 1992;80:1105–1115
  28. Papadaki HA, Marsh JC, Eliopoulos GD. Bone marrow stem cells and stromal cells in autoimmune cytopenias. Leuk Lymphoma. 2002;43:753–760
  29. Krantz SB. Erythropoietin. Blood. 1991;77:419–434
  30. Barosi G. Inadequate erythropoietin response to anemia: definition and clinical relevance. Ann Hematol. 1994;68:215–223
  31. Cazzola M, Ponchio L, de Benedetti F, et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anaemia associated with systemic-onset juvenile chronic arthritis. Blood. 1996;87:4824–4830
  32. Xiao W, Koizumi K, Nishio M, et al. Tumor necrosis factor-alpha inhibits generation of glycophorin A+ cells by CD34+ cells. Exp Hematol. 2002;30:1238–1247
  33. Taniguchi S, Dai CH, Price JO, Krantz SB. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells. Blood. 1997;90:2244–2252
  34. de Vos S, Brach MA, Asano Y, et al. Transforming growth factor-beta 1 interferes with the proliferation-inducing activity of stem cell factor in myelogenous leukemia blasts through functional down-regulation of the c-kit proto-oncogene product. Cancer Res. 1993;53:3638–3642
  35. Khoury E, Andre C, Pontvert-Delucq S, et al. Tumor necrosis factor alpha (TNF alpha) downregulates c-kit proto-oncogene product expression in normal and acute myeloid leukemia CD34+ cells via p55 TNF alpha receptors. Blood. 1994;84:2506–2514
  36. Dubois CM, Ruscetti FW, Stankova J, Keller JR. Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors. Blood. 1994;83:3138–3145
  37. Broudy VC, Lin N, Brice M, Nakamoto B, Papayannopoulou T. Erythropoietin receptor characteristics on primary human erythroid cells. Blood. 1991;77:2583–2590
  38. Papadaki HA, Pontikoglou C, Stavroulaki E, et al. Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. Ann Hematol. 2006;85:170–173
  39. Besmer P. Kit-ligand–stem cell factor. In:  Garland JM,  Quesenberry PJ,  Hilton DJ editor. Colony-stimulating factors: Molecular and cellular biology. New York: Marcel Dekker; 1997;p. 369–404
  40. Uoshima N, Ozawa M, Kimura S, et al. Changes in c-Kit expression and effects of SCF during differentiation of human erythroid progenitor cells. Br J Haematol. 1995;91:30–36
  41. Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP. Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol. 1995;165:538–546
  42. De Maria R, Testa U, Luchetti L, et al. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood. 1999;93:796–803
  43. Jacobsen SE, Ruscetti FW, Dubois CM, Keller JR. Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation. J Exp Med. 1992;175:1759–1772
  44. Weiss G, Goodnough LT. Anaemia of chronic disease. N Engl J Med. 2005;352:1011–1023

PII: S0301-472X(06)00327-4

doi: 10.1016/j.exphem.2006.05.010

Experimental Hematology
Volume 34, Issue 10 , Pages 1312-1322 , October 2006

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