Experimental Hematology
Volume 30, Issue 10 , Pages 1193-1201 , October 2002

Reversible switching of expression of c-kit and Pax-5 in immature hematopoietic progenitor cells by stromal cells

Received 15 February 2002 ,Revised 14 May 2002 ,Accepted 12 June 2002.

References 

  1. Fuchs E, Segre JA. Stem cells (a new lease on life). Cell. 2000;100:143
  2. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature. 2001;414:98
  3. Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science. 1996;273:242
  4. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91:661
  5. Yanai N, Matsui N, Matsuda K-I, et al.  A novel stromal cell-dependent hematopoietic cell line established from temperature-sensitive SV40 T-antigen transgenic mice. Exp Hematol. 1999;27:1087
  6. Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of hematopoietic stem cell in vitro. J Cell Physiol. 1977;91:335
  7. Whitlock CA, Witte ON. Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci U S A. 1982;79:3608
  8. Okuyama R, Koguma M, Yanai N, Obinata M. Bone marrow stromal cells induce myeloid and lymphoid development of the sorted hematopoietic stem cells in vitro. Blood. 1995;86:2590
  9. Koguma M, Matsuda K, Okuyama R, Yanai N, Obinata M. Selective proliferation of lymphoid cells from lineage− c-Kit+ Sca-1+ cells by a clonal bone marrow stromal cell line. Exp Hematol. 1998;26:280
  10. Okubo T, Matsui N, Yanai N, Obinata M. Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture. Cell Struct Funct. 2000;25:133
  11. Okubo T, Yanai N, Obinata M. Self-renewal and differentiation of a novel bipotent myeloid progenitor clone in the stroma-dependent culture. Exp Hematol. 2000;28:651
  12. Yanai N, Matsuya Y, Obinata M. Spleen stroma cell lines selectivity support erythroid colony formation. Blood. 1989;74:2391
  13. Li Y, Wasserman R, Hayakawa K, Hardy RR. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 1996;5:527
  14. Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity. 1997;7:483
  15. Urbanek P, Wang Z, Fetka I, Wagner EF, Busslinger M. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell. 1994;79:901
  16. Dorshkind K. Transcriptional control points during lymphopoiesis. Cell. 1994;79:751
  17. Rothenberg EV, Telfer JC, Anderson MK. Transcriptional regulation of lymphocyte lineage commitment. Bioessays. 1999;21:726
  18. Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage dependents on the transcription factor Pax-5. Nature. 1999;401:556
  19. Yanai N, Sekine C, Yagita H, Obinata M. Roles for integrin very late activation antigen-4 in stroma-dependent erythropoiesis. Blood. 1994;83:2844
  20. Holloway W, Martinez AR, Oh DJ, Francis K, Ramakrishna R, Palsson BO. Key molecules are present on long podia extended by hematopoietic cells. Cytometry. 1999;37:171
  21. Ehlich A, Schaal S, Gu H, Kitamura D, Muller W, Rajewsky K. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell. 1993;72:695
  22. Matsuda K, Koguma M, Okuyama R, et al.  A novel stromal cell-dependent B lymphoid stem-like cell line that induces immunoglobulin gene rearrangement. J Biochem. 1999;125:602
  23. Li Y-S, Hayakawa K, Hardy RR. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med. 1993;178:951
  24. Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 1998;391:904
  25. Hunte BE, Capone M, Zlotnik A, Rennick D, Moore TA. Acquisition of CD24 expression by Lin−CD43+B220(low)ckit(hi) cells coincides with commitment to the B cell lineage. Eur J Immunol. 1998;28:3850
  26. Mojica MP, Perry SS, Searles AE, et al.  Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow. J Immunol. 2001;166:3042
  27. Wang J, Walker H, Lin Q, et al.  The mouse BP-1 gene (structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7). Genomics. 1996;33:167
  28. Kondo M, Scherer DC, Miyamoto T, et al.  Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature. 2000;407:383
  29. Katsura Y. Redefinition of lymphoid progenitors. Nat Rev Immunol. 2002;2:127
  30. Arroyo AG, Yang JT, Rayburn H, Hynes RO. α4 Integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity. 1999;11:555
  31. Payne KJ, Medina KL, Kincade PW. Loss of c-Kit accompanies B-lineage commitment and acquisition of CD45R by most murine B-lymphocyte precursors. Blood. 1999;94:713
  32. O'Riordan M, Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity. 1999;11:21
  33. Lin H, Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 1995;376:263
  34. Nutt SL, Urbanek P, Rolink A, Busslinger M. Essential functions of Pax5 (BSAP) in pro-B cell development (difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus). Genes Dev. 1997;11:476
  35. Nutt SL, Vambrie S, Steinlein P, et al.  Independent regulation of the two Pax5 alleles during B-cell development. Nat Genet. 1999;21:390
  36. Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood. 1996;87:4025
  37. Hu M, Krause D, Greaves M, et al.  Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 1997;11:774
  38. Watt FM, Hogan BL. Out of Eden (stem cells and their niches). Science. 2000;287:1427
  39. Yee NS, Langen H, Besmer P. Mechanism of kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells. J Biol Chem. 1993;268:14189
  40. Broudy VC, Lin NL, Liles WC, et al.  Signaling via Src family kinases is required for normal internalization of the receptor c-Kit. Blood. 1999;94:1979
  41. Nutt SL, Morrison AM, Dorfler P, Rolink A, Busslinger M. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of function experiment. EMBO J. 1998;17:2319

PII: S0301-472X(02)00899-8

Experimental Hematology
Volume 30, Issue 10 , Pages 1193-1201 , October 2002

Article Tools

* Image Usage & Resolution